The solvent effect on the Grignard reaction of benzyl, aryl and heteroaromatic substrates has been systematically evaluated based on reaction efficiency, ease of subsequent work-up, safety and greenness. 2-Methyltetrahydrofuran (2-MeTHF), which can be derived from renewable resources, had at least an equal if not a superior overall process most notably in suppressing the Wurtz coupling by-product from the benzyl Grignard reactions. It is therefore a recommended alternative solvent to Et 2 O and THF for the preparation of most Grignard reagents and their subsequent reactions. † Electronic supplementary information (ESI) available. See

In this paper, we develop a general framework for studying Dirichlet Boundary Value Problems (BVP) for second order symmetric implicit differential systems satisfying the Hartman-Nagumo conditions, as well as a certain non-expandability condition. The main result, obtained by means of the equivariant degree theory, establishes the existence of multiple solutions together with a complete description of their symmetric properties. The abstract result is supported by a concrete example of an implicit system respecting D 4 -symmetries.

Biodiesel is a promising alternative to fossil fuels and mainly produced from oils/fat through the (trans)esterification process. To enhance the reaction efficiency and simplify the production process, various catalysts have been introduced for biodiesel synthesis. Recently, the use of bio-derived catalysts has attracted more interest due to their high catalytic activity and ecofriendly properties. These catalysts include alkali catalysts, acid catalysts, and enzymes (biocatalysts), which are (bio)synthesized from various natural sources. This review summarizes the latest findings on these bio-derived catalysts, as well as their source and catalytic activity. The advantages and disadvantages of these catalysts are also discussed. These bio-based catalysts show a promising future and can be further used as a renewable catalyst for sustainable biodiesel production.

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