Lymphopenia developing at the early stage of chronic graft-versus-host reaction is associated with increased content of IL-7 in the peripheral blood and leads to an increase of the CD4(+)and CD8(+)cell subpopulations in the spleen of the recipient. After 3 months, some animals develop autoimmune glomerulonephritis (lupus recipients). High levels of IL-7 and T-cells with the memory cell phenotype (CD4(+)CD45RB(low)and CD8(+)CD45RB(low)) persist in these animals, in contrast to nonlupus recipients without signs of autoimmune disease. This can attest to the involvement of homeostatic proliferation processes in the formation of autoimmune disease in this model.

Introduction. Stomach doubling is one of the rarest types of gastrointestinal doubling in the system of pathology of abdominal organs in children. Stomach doubling occurs in 4–8% of cases of gastrointestinal doubling. To a greater extent, it is diagnosed in girls. The rarest localization of doubling is a small curvature of the stomach — 7%.The purpose of the study: to present the informative value of radiation methods in the diagnosis of gastric doubling by the example of a clinical case.Material and methods. The work is based on the analysis of clinical data, instrumental, histological studies performed in a children’s hospital in St. Petersburg.Results: An 8-year-old patient was hospitalized for further examination for cystic formation of the abdominal cavity, detected antenatally at 36 weeks of gestation. At the age of 2 years, MSCT angiography of the abdominal cavity was performed and a differential series between a liver cyst and a doubling of the stomach was exposed. At the control ultrasound, further negative dynamics in size. An MRI revealed that the picture most likely corresponds to a cystic doubling of the stomach. Indications for surgical treatment are exposed. Histologically confirmed variant of stomach doubling.Conclusion. The multimodal approach allows timely diagnosis of the presented pathology, differential diagnosis of gastric doubling with rare localization and determination of indications for surgical treatment.

Антиэрготипический ответ: влияние нА иммунный ответ и рАзвитие Аутоиммунной пАтологии в эксперименте Ильина Н.А., Гойман Е.В., Кудаева О.Т., Колесникова О.П., Кожевников В.С. Лаборатория клинической иммунопатологии, лаборатория экспериментальной иммунотерапии НИИКИ СО РАМН, г. НовосибирскРезюме. Одним из механизмов, ограничивающих экспансию аутореактивных Т-лимфоцитов, уча-ствующих в развитии аутоиммунной патологии, являются анти-эрготипические клетки, которые реа-гируют на экспрессию на поверхности активированных Т-клеток маркеров активации -эрготопов. В работе показано развитие иммунного ответа на вакцинацию анти-CD3-активированными синген-ными спленоцитами, выражающееся в виде реакции ГЗТ. При этом не наблюдалось изменения нор-мального клеточного и гуморального иммунного ответа. В реакции хронической РТПХ показано, что иммунизация доноров оказывает протективное действие в отношении сроков наступления протеину-рии у реципиентов, тогда как иммунизация реципиентов не меняет течение РТПХ. Abstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated syngeneic splenocytes to induce anti-ergotypic response and to assess immune response in delayed-type hypersensitivity (DTH) reaction. DTH response in experimental group was significantly greater than in control and intact groups. Upon crossadministration, DTH response was minimal and there were no significant differences between the groups. No changes in cellular and humoral immune response were observed under such conditions. These results suggest a development of immune response to activated antigen-nonspecific cells. In a model of chronic GvHD, donor immunization was shown to exert a protective effect, with regard of proteinuria dynamics in recipients, whereas immunization of recipients did not alter the GvHD dynamics.

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