Background: Vertigo is an illusory sense of motion in the absence of real movement, either in the self or the environment. Vertigo is isolated and has no positive indications of dysfunction of the central neurological system. Study aims at studying MRI, TCD and BAEP relationships and alterations in individuals with isolated vertigo. Methods: Patient control research involves 50 patients with isolated vertigo, 50 matched age and gender health controls, from Al-Azhar University Hospitals, Assuit, Egypt, neurology and audio vestibular hospitals, from May 2019 through to June 2021. Results: patient start age with vertigo (40-60), disease duration (2-3) years, 70% with peripheral vertigo,30% with central vertigo, 86% with abnormal and 70% with abnormal BAEP and 74% with vertigo with an abnormal TCD. Relationship and variations in cervical MRI, TCD and BAEP in 50 patients with "isolated" vertigo and 50 healthy controls respectively were examined. Results: A statistically significant differences between the two groups were found for total TCD, BAEP abnormalities and no significant differences between the two groups in cervical MRI abnormalities. The findings revealed strong associations between TCD and cervical MRI, TCD and BAEP in the vertigo group. And TCD PI analysis and certain BAEP items revealed positive linear relationships. In the control group, there were no statistical differences or relationships. Conclusions: TCD is a "isolated" vertigo screening sensitive technique. A combined cervical MRI, TCD and BAEP test regimen is suited to evaluate the "isolated" vertigo.

Background: Chronic idiopathic polyneuropathy is asymmetrical, axonal damage involving large fibres of insidious onsets is disclosed in neurophysiologic long-dependent neuropathy and slowly progressive course over a minimum of six months without aetiology can be identified despite the appropriate investigations. This research was designed to investigate idiopathic polyneuropathy individuals. Methods: The comparative patient control research comprised 20 patients selected from 127 polyneuropathic and 20 matching age or sex controls from the Al-Azhar University Neurology Clinic at Assuit Hospitals, April 2019 to May 2021. Results: Age of onset of idiopathic polyneuropathy patients (47-73), length of disease (1-6) years (60%), DN4 score (5-7), abnormal pine brick (80%), abnormal vibrations (90%), abnormal fine touch (75%), distal weaknesses (70%) losing ankle (90%) and wasting (20 percent ). This represents significant variations in the amplitude of decreased motor-action compounds and the reduced speed of median,ulnar, tibial peroneal nerves across the tested groups. Significant variations between tibial and peroneal tissues are also seen in prolonged distal latency, decreased sensory amplitude and extended latency between sensory (median, ulnar, and sural) nerves. The delay differences and a reduced amplitude of sympathetic cutaneous response across the investigated groups are significant. There are also substantial differences in the intraepidermal nerve fibre density decrease in skin biopsy from the distal leg between idiopathic polyneuropathical patients and control groups. Conclusion: Intraepidermal nerve fibre density in skin biopsy is responsive to idiopathic polyneuropathy than standard neurophyological investigations.