Relevance. Respiratory diseases, flu and pertussis, in particular, are common causes of temporary disability at work place. Pertussis is the second most common infectious disease by incidents increase in the Russian Federation. Combined immunization is found to be an efficient method to prevent infections at work place.Objective. Research objective is to prove safety of combined influenza and the diphtheria-tetanus-pertussis vaccines for people with occupational hazard of respiratory diseases.Materials and methods. We have studied the vaccination process in 257 adults with 2-nd and 3-rd health groups. We evaluated post-vaccination reactions, their localization, severity, time onset, and duration. We identified two groups with weaker and stronger side effects after vaccination. We determined typical parameters of the vaccination process.Results. 50% people in examined group showed adverse reaction. Symptoms were weak as a rule and lasted up to 4 days mostly. 29 people (11%) had more severe and long reaction. 6 patients (2%) required supportive care, 2 (0.8%) showed severe symptoms lasting from 2 to up to 5 days.Conclusion. The application of influenza vaccination combined with diphtheria, tetanus and pertussis vaccinations simultaneously have demonstrated that it is safe to use in adults at risk of exposure for respiratory diseases at workplace. Minor side effects do not pose a health threat, and can be completely prevented.

Introduction. The exposure to industrial aerosols triggers the response of the adaptive and innate mucosal immunity in the upper airways. Objective: To analyze the impact of work-related risk factors on the development of local mucosal immunity in workers engaged in extraction of vanadium-bearing iron ore, and cast iron and steel production. Materials and methods. We examined one thousand five hundred forty seven male workers of two mining and metallurgical industries. The first cohort included 788 vanadium-bearing iron ore miners and the second cohort comprised 719 cast iron and steel production workers, both standardized by age and years of employment. Occupational risk factors identified in both cohorts included the exposure to fibrous aerosols and aliphatic hydrocarbons, and poor microclimate (high or low air temperature) at workplaces. The workers of the second cohort were also exposed to manganese compounds, vanadium (V) oxide, chromium, nickel, and iron compounds. The control group consisted of 40 engineering and technical personnel. Results. A significant increase in secretory immunoglobulin A (sIgA) was detected in the miners exposed to aliphatic hydrocarbons and low air temperature. In the ferrous metallurgy workers, the exposure to low air temperature, crystalline silicon, and aliphatic hydrocarbons caused a significant decrease in the level of sIgA while the exposure to manganese oxides induced a decrease in the bactericidal function of neutrophils. Limitations. The main limitations of the research were related to the selected criterion of inclusion in the merged occupational cohorts with account for exposure to adverse microclimate parameters, silicon-containing aerosols, aliphatic hydrocarbons, and manganese compounds. In view of the multiplicity of occupational risk factors in the industry, it is important to conduct additional studies of a larger sample for qualitative and quantitative presentation of convincing evidence of health effects of other factors of the work environment. Conclusions: We established a multidirectional response of the mucosal immunity to production factors in the examined workers. A combined exposure to chemical and physical occupational factors has a stronger health effect than a single one. Differences in the level of sIgA in workers exposed to different occupational hazards prove the advisability of an in-depth immunological examination combined with an assessment of the functional status as indicators of occupational adaptation.

Relevance. Local vibration is a significant factor in the production environment of metallurgical production, which affects health and efficiency. The aim of the study is to identify the exposure, gender and age features of the formation of general somatic morbidity associated with the impact of local vibration in the production of titanium alloys. Scope and methods. The prevalence of general somatic pathology was compared in 2596 workers who have contact with local vibration, with varying degrees of harmfulness of working conditions, and non-exposed persons according to the results of periodic medical examination using the methodology of occupational risk analysis of the Research Institute of Occupational Medicine. academician N. F. Izmerov. Results. At comparison of prevalence of a somatic pathology at workers in contact to local vibration to not exhibited persons according to medical inspection, and at different degree of harm of working conditions, are revealed the raised risks of formation of diseases nervous, kostno-muscular, endocrine systems, respiratory organs, digestion, an ear, a skin, an arterial hypertensia, the mental frustration, the raised weight of a body, gynecologic diseases with a tendency of growth of the majority of them at the big levels of vibration, more often at small, less often - average degree of communication with working conditions. The frequency of pathology in exposed workers was higher in all age groups. Average degree of communication with working conditions of a gynecologic pathology at the age of 18-25 years was marked. At men frequency of a pathology of respiratory organs, digestion is revealed authentically big, than at women; an ear; skin at the big relative risks 1,2-1,3, of the raised arterial pressure and hyperglycemia. Conclusion. A higher frequency of visceral pathology of a number of body systems under the influence of local vibration of high levels may justify the need to develop differentiated preventive programs to minimize its negative impact, taking into account the identified features in sex and age groups.

Introduction. Most studies on the morbidity of workers with fluorine compounds are devoted to occupational medicine at aluminium industry enterprises. The aim of the study is to identify the exposure, gender and evolutionary features of the formation of general somatic morbidity associated with chronic occupational exposure to hydrofluoride in the production of titanium alloys. Materials and methods. The analysis of the prevalence of chronic pathology according to the medical examination of 562 workers in contact with hydrofluoride and the incidence of temporary disability according to 29949 disability sheets in comparison with non-exposed persons of the same enterprise is given. Results. With an increase in the degree of harmfulness of working conditions, there was an augmentation increase in the risk of developing pathology of the respiratory organs, eyes, musculoskeletal system, arterial hypertension and hypercholesterolemia. In the working conditions of Class 3.1, an increased prevalence of diseases of the nervous and genitourinary systems with a moderate degree of occupational conditionality was revealed (relative risks (RR) 1.6 and 2.0, respectively, р < 0.05), class 3.2 - a high degree of professional conditionality of respiratory diseases (RR = 2.8). When working in harmful working conditions, there was an average degree of occupational conditionality of nervous system diseases in women (RR = 1.9) and a small degree of arterial hypertension in men (RR = 1.2). The prevalence of general somatic pathology in all age groups was higher than in non-exposed persons of the same age. Conclusion. Hydrofluoride in the production of titanium alloys was proved to be a trigger contributing to the formation of the pathology of the respiratory, circulatory, digestive, ear, eyes, skin, blood, musculoskeletal, nervous, endocrine, and genitourinary systems.