Objective. Studying of mutual role of the main pathogenetic factors of abdominal sepsis – the inflammation origin and intraabdominal hypertension, from the one side, endotoxicosis and the abdominal compression syndrome (ACS), from the other side. Materials and methods. Into the investigation 196 patients with abdominal sepsis were included, in whom after the certain preliminary preparation the operative procedure was done. The levels of neutrophils, macrophages, interleukin–6, interleukin–10 in peritoneal exudate were studied as indices of the inflammation source for abdominal cavity. These indices were characteristic for systemic answer on general reaction, the degree of which have determined the abdominal sepsis course and result. Determination of intraabdominal pressure was applied for estimation the intraabdominal hypertension role in abdominal sepsis. Results. The ratio of the endotoxicosis and the ACS indices in the complications structure, not dependent on some differences due to the complication type present, was practically similar. Conclusion. The results of the investigation conducted, witnesses the presence of interrelationship of roles of endotoxicosis and the abdominal compression syndrome in pathogenesis of abdominal sepsis, their indices changes are characterized by mutual activity strengthening, accompanied by clinical manifestations of the organs dysfunction, determining the severity of course and result of pathological process in the organism.