This paper provides information on the technology of manufacturing dosage forms from local plant materials. According to the developed technique, alcohol, water extracts and tincture from the collection of medicinal plants were prepared. Studies have revealed that in order to obtain a larger amount of concentrated extract, it is better to use distilled water as an extractant for plantain leaves, foalfoot and oregano herbs, and 70% ethyl alcohol for licorice root and horsetail herb. The results obtained indicate that extracts of medicinal plants have a pronounced antibacterial effect against pathogenic pathogens St. aureus, St. pyogenes, E. coli. The acute toxicity and cumulative properties of the extracts were determined. It was found that the prepared extracts from the collection of medicinal plants did not have a pronounced toxic effect on the body of white mice and rats, as evidenced by the absence of obvious negative effects on the clinical and morphological parameters of blood. The results of measuring the absolute mass of the body and internal organs showed that under the influence of the extracts, their growth was stimulated, which indicated the absence of a harmful organotropic effect. It was revealed that phytopreparations do not potentiate the effect of histamine, as evidenced by their lack of allergenic properties. Biochemical studies of blood serum in rats receiving phytopreparations revealed shifts in the quantitative content of protein, glucose, urea, and aminotransferase activity, and these parameters were within the physiological norm, and morphological parameters also did not exceed physiological parameters.

The analysis of the presented data shows that keratoconjunctivitis is quite often registered in cattle. Therefore, new medicinal substances have been developed for its treatment, namely, a polycomponent ointment and a phyto-ointment from local plant raw materials. As a result of the conducted research, reliable data were obtained indicating the beneficial effect of the developed ointments on individual biochemical blood parameters in sick animals. Studies have established that the complex application of the developed ointments contributes to the bio-correction and bio-normalization of metabolic processes in the body of sick animals, which is expressed by a significant increase in the quantitative values of hematological parameters, total protein and its fractional composition, β-lysine, lysozyme, lactoferrin, and bactericidal activity of blood serum. In the course of treatment, the greatest therapeutic effectiveness was established in the 3rd experimental group of animals, which used a combined treatment regimen with the alternating use of multicomponent ointment the Kazakh Scientific Research Veterinary Institute LLP (KazSRVI) and phyto-ointment KerKon. After applying the combined scheme, 33.3% of animals recovered by the 10th day from the start of treatment, and the full recovery of the majority of sick animals occurred within 11-16 days (66.7%). The obtained results of the research and production experiment showed that the most acceptable method was the use of a combined treatment regimen for sick animals, where the absolute effectiveness was 100%, compared to 80% in the control group.

No abstract