Background In contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity. Methods and results CLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure. Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest. Conclusion In patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes. ClinicalTrials identifier ISRCTN43070564

The relevance of the study is due to the high prevalence of inflammatory periodontal diseases in patients with cardiovascular pathology. Currently, for the treatment of ischemic heart disease (IHD), statins are used, which, in addition to hypolipidemic action, have anti-inflammatory properties, which can lead to an increase in the pressure of the inflammatory process, not only in heart vessels, but also in paradonte.The aim of the study was to study the effect of prolonged use of statins on the course of inflammatory periodontal diseases in patients with IHD.Materials and methods. A dental examination and study of the quality of life of 122 patients with ischemic heart disease (IHD) were performed. Surveyed were divided into two groups depending on the duration of receiving lipid-corrective therapy.The results of the study. It has been established that in patients with coronary artery disease who take statins for a long time, the periodontal inflammation activity and the severity of its clinical manifestations are lower than in patients not using lipid-correcting therapy, which was accompanied by improvement in certain parameters of quality of life.

Relevance. The COVID-19 pandemic significantly affected the stress levels of healthcare workers. Like some other medical specialties, dentists have the highest risk of infection due to close contact with the patient's oral cavity and aerosol-generating procedures.Purpose. The study aimed to study the impact of the COVID-19 pandemic on the stress level of dentists in Novosibirsk.Material and methods. The study involved 273 dentists of various specialties aged from 20 to 65 years. The study assessed the overall level of perceived stress, overstrain and counteraction to stress using the "Perceived stress scale" (PSS-10). The Peritraumatic Distress Inventory (PDI) evaluated the level of distress associated with the pandemic.Results. The overall level of perceived stress is sufficiently high in all groups; the indicators increase with age from 6.9% in the younger age group to 95.7% in the older one. Older dentists are aware of the higher risks of a severe course and consequences of the disease and fear for the lives of loved ones. In the middle and younger age groups, the level of distress associated with professional activities is within the normal range. The older age group showed a high peritraumatic distress level associated with practising medicine during the COVID-19 pandemic. Gender differences in the perceived stress and distress levels were not found.Conclusion. The COVID-19 pandemic caused an increase in the psychological stress level among dentists, especially among older age groups. The study allowed us to identify factors affecting stress levels, which must be considered when organizing effective psychological assistance to doctors during epidemics of infectious diseases and providing targeted help to those in need.

Relevance. Numerous epidemiological studies have found a high degree of association between DM and periodontal disease, and periodontal disease has even been proposed as a sixth complication of DM. It has also been demonstrated that this relationship is bidirectional, with periodontitis exerting an effect on DM. These fndings have diagnostic and therapeutic implications. Thus, the high prevalence of periodontal disease in DM indicates the need to evaluate glucose levels in periodontal patients. Conversely, intervention studies have demonstrated that the treatment of periodontal disease improves the glycemic control of DM patients. To alert health professionals about the risk that periodontitis represents for the onset or exacerbation of complications in individuals with type 2 diabetes mellitus (DM) and to emphasize that the mechanical treatment of periodontal disease and reestablishment of oral health are essential for the metabolic control of these patients.Materials and methods. A review of the literature on the topic of 30 sources from them 5 domestic and 25 foreign data.Some researchers demonstrate the Periodontal screening must be part of the overall clinical examination of patients with diabetes and, if diagnosed, periodontal disease must be treated appropriately to avoid or exacerbate diabetes complications besides improving glycemic control in these individuals.Results: In the postoperative period during the frst three days, patients of both groups had moderate soft tissue edema, slight flap hyperemia and palpation pain.Conclusions. Increased knowledge of dentists, endocrinologists and the public is required to improve early diagnosis of diabetes, adequate management, prevention and treatment of dental diseases in patients with DM.

Relevance. Inflammatory periodontal diseases, with a 68-98% prevalence, are a risk factor for developing cardiovascular diseases (CVD). There is simultaneously a low awareness of dental diseases and their role in assessing general health. The patient's understanding of the need for prevention and treatment of dental diseases is essential in the successful treatment of cardiovascular diseases. In this regard, the study of dental treatment adherence in patients with cardiovascular diseases is particularly relevant. Purpose – to study the level of adherence to dental treatment in patients with cardiovascular diseases.Materials and methods. We conducted a dental examination and survey of 121 patients aged 18 to 89 years during treatment of coronary artery disease clinical manifestations, including 48 men and 73 women. The average age of the surveyed was 65.2 ± 0.44 years. Patients completed a modified Morisky-Green questionnaire, which included four questions. We used a written questionnaire, which included 21 closed questions of the original questionnaire, to study the factors affecting adherence to dental treatment.Results. The study found that 87.6% of cardiovascular patients poorly adhered to dental treatment, 9.1% of patients were at risk, and only 3.3% had strong adherence to treatment. Only half of the respondents (52%) believed that oral diseases could affect the underlying disease course. Adherence to dental treatment did not depend on the age of the examined patients. Adherence was higher among women and those with higher education.Conclusion. The study revealed that patients with cardiovascular diseases have a high prevalence and intensity of inflammatory periodontal diseases and low adherence to their treatment. Only half of the patients know the relationship between cardiovascular diseases and inflammatory periodontal dis eases.