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Introduction: Acute pancreatitis (AP) is known to cause cascade of complex inflammatory response following an initial insult. Hence the scoring systems includes white blood cell count (WBC). This study analyse the inflammatory responses between gallstone pancreatitis (GP) versus non-galltone pancreatitis (NGP). Methods: All patients presented with AP between October 2016 to October 2017 were included in this study and relevant parameters were collected from an electronic patient documents. Total of 140 patients were analysed in this study. We have collected the WBC count and C-reactive protein (CRP) at admission, 24 hours and 72 hours to assess their response to AP. Results: Among 140 patients with acute pancreatitis, 33 patients had GP and remaining of 107 patients suffered NGP. The WBC count at admission, 24 hours and 72 hours in GP versus NGP were (11.6AE 5 versus 13.7AE17; P=.24), (12.6AE20 versus 10.1AE17;P=0.21) and (13.2AE22 versus 9.2AE4.7;P=0.15) respectively. But the CRP levels at admission, 24 hours and 72 hours were (30.4AE 73 versus 47.6AE79; P=0.25), (71.9AE20 versus 92.2AE97; P=0.35) and (89AE106 versus 122.7AE107; P=0.05) respectively. Conclusion: There was a significantly high CRP level was associated with non-biliary pancreatitis. Further investigation is needed to assess this response and perhaps this could shed on evolution of AP.