Rhizome rot disease of ginger has become a major threat to all ginger growing areas causing huge economical losses. The complex nature of the pathogens involved in the disease makes the management strategies cumbersome. There is still a need to develop integrated disease management strategies by targeting all the pathogens involved in the complex disease development. In the present study, we have isolated five pathogens involved in the disease development such as Pythium, Fusarium, Sclerotium rolfisii, Ralstonea solanacearum and Meloidogyne incognita. A primary in vitro evaluation of seven different antibiotics such as Streptocycline, K-cycline, Plantomycine, Validamycin, Bactinash, Bactinashak as well as nine nonsystemic, eleven systemic, and twelve combi products were evaluated under lab conditions against the pathogen complex. Our results revealed that among the different antibiotics Streptocycline followed K-cycline, Bactinash, as well as COC, found most effective against Ralstonea solanacearum. Among the different non-systemic chemicals evaluated against the pathogen complex COC and propineb found effective against Pythium, mancozeb, captan, kavach were effective against Fusarium and all the non-systemic fungicides showed high inhibition against Sclerotium rolfisii. Systemic fungicides such as carbendazim, Tricyclazole, Tebuconazole, Alliete were found more effective against Pythium. Tricyclazole, Tebuconazole found effective against Fusarium, and fungicides such as Hexaconazole, Propiconazole, Tricyclazole, Myclobutanil, Azoxystrobin, Tebuconazole, Diniconazole were found effective against Sclerotium rolfsii. As compared to systemic and non-systemic fungicides, combi products were found more effective against all the pathogens involved in the disease complex.