Nowadays, along with significant intellectual and emotional burdens, students are exposed to even more threatening stressogenic factors. Therefore, scientific research aimed at the study of the factors that trigger the mechanisms of stress development in students of higher education is becoming more and more relevant. The purpose of the study is to investigate the influence of motor activity on the factors causing stress-related conditions in students of higher education. Research methods: study, analysis, systematization and generalization of scientific-methodical and special literature, own pedagogical experience, pedagogical observations. The results. The concept of "stress-associated conditions of students of higher educational institutions" was clarified, by which we mean the spectrum of persistent psycho-emotional experiences and reactions of the students' body to adverse changes in the environment. Among the most threatening factors causing stress in students, we identified: the transformation of the socio-cultural situation in the sphere of leisure, entertainment, communication at the stage of digitalization of society, caused by the formation and development of e-sports; a change in the study regime, the impossibility of attending wellness events due to quarantine restrictions, a violation of the established way of life under the influence of armed conflicts. Despite the leading role of health-recreational motor activity in overcoming stress and reducing the severity of its impact on the condition of students of higher education, the selected factors do not contribute to such activity. This can increase the impact of stress on students and exacerbate stress-related conditions. Conclusions. It is necessary to develop and implement a system of prevention and correction of stressful conditions of students of higher educational institutions by means of health and recreational motor activity.