A Series of 4-methyl-3-[5-(substituted phenyl)-4, 5-dihydro-1H-Pyrazol-3-yl] Cinnoline-6-Sulfonamide were synthesized from 4-methyl-3-acetylcinnoline-6-Sulfonamido chalcones and hydrazines. The structure of the synthesized compounds were characterized by UV, IR, NMR & Mass spectral data, and evaluated for their in vitro anti-malarial and anti-bacterial activity to get new congeners as analogs of Pyrazole based Cinnoline compounds as a potent anti-Malarial and anti-microbial agents. All analogues exhibited in vitro anti-malarial activity against Plasmodium falciparum and all the analogues showed good anti-bacterial activity against various pathogenic microbes.

Venomous snakebite is a global serious health issue and in India high rate of mortality is caused by Naja naja (Indian cobra). To evaluate anti-cobra venom activity and identify lead molecules in Aegle marmelos, in vitro and in silico screening was carried out. Leaves, stem and root bark of A. marmelos were extracted in ethanol, methanol and hexane and maximum yield was obtained in methanol. All extracts were used for testing in vitro anti-haemolytic, inhibition of antiacetylcholinesterase and anti-proteolytic activities. The results revealed that ethanol extract of root bark has high anti-haemolytic activity, methanol extracts of leaves have the highest inhibitory effect on venom induced anti-acetylcholinesterase activity and ethanol extracts of leaves have maximum anti-proteolytic activity. Docking between 81 phytochemicals from A. marmelos and each of the 14 cobra venom toxic proteins revealed that the plant contains potential molecules for detoxification of all the cobra venom proteins.

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