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Malformations of the lower extremities are rare and poorly described. Although fibular agenesis is the most common lower extremity malformation, there are few published cases of prenatal diagnosis. We report a clinical case of fibular agenesis that was presented at the Hospital de Carabineros de Chile and its subsequent discussion.Supporting information can be found in the online version of this abstract EP10.05 Relationship between absent or hypoplastic fetal nasal bone at 20-23 +6 weeks of gestation and chromosomal defects in an unselected Chinese population L. CaoUltrasonic Diagnosis Department of Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China Objectives: To investigate the relationship between absent or hypoplastic fetal nasal bone and chromosomal defects during the second trimester in an unselected Chinese population. Methods: From January 2012 to December 2015, included were 58133 pregnant women who underwent routine ultrasound examination between 20 and 23+6 gestational weeks as a screening test. We collected all the cases of absent or hypoplastic fetal nasal bone, followed up the results of karyotype analysis and the information on neonatal development. Results: (1)150 fetuses were found to have absent or hypoplastic fetal nasal bone in the 58651 fetuses(2.56‰), of which 57636 were singleton,476 were twins and 21 were triplets. With 14 cases of misdiagnosis, missing or incomplete data excluded,136 cases were included in the study. 113 underwent interventional prenatal diagnostic test, and fetal chromosomal defects were detected in 24 cases (17.6%), including 18 cases (75%) of Trisomy 21, 3 cases (12.5%) of Trisomy 18, 1 case (4.2%) of Klinefelter syndrome and 2 cases (8.3%) of microdeletion syndrome. (2) There was no significant difference in the incidence of chromosomal defects between absent fetal nasal bone and hypoplastic fetal nasal bone[22.5%(16/71) vs 12.3%(8/65),x2=2.442, P=0.118]. (3) The incidence of chromosome defects in fetuses without other structural defects was significantly lower than that with structural defects [3.9%(3/76) vs 35.0% (21/60), corrected x2=22.247,P=0.000]. (4)A total of 38 cases of Down syndrome were found in 56707 cases of delivery or induced labour in our hospital. When the fetal nasal bone dysplasia was used as an indicator of Down's syndrome, the sensitivity was 47% and the specificity was 99.8%. Conclusions: The absent and hypoplastic fetal nasal bone are closely related to fetal chromosomal defects. When combined with other sonographic defects, it is necessary to carry out a detailed prenatal diagnosis to exclude fetal chromosomal defects. Objectives: In our routine examinations we noticed that we could follow fetal swallowing using colour Doppler -we tried to study if this technique could be used to monitor the contour of the fetal palate in order to screen for posterior palate defects. Methods: We shared the idea with our team in the Prenatal Diagnosis Unit and we monitored the accessibility of HD -Flow in assessing the contour of the f...

Objectives: Ultrasound has important role in diagnosing and evaluating treatment response to cervical carcinoma. Superb Microvascular Imaging (SMI) is a notable ultrasound technology that can remove motion artefact and visualise low blood flow. To investigate the efficacy of SMI in cervical carcinoma, we used SMI in patients with advanced cervical carcinoma through neoadjuvant chemotherapy. Methods: Between 2016 and 2017, we enrolled patients with cervical carcinoma. All patients received Paclitaxel, Cisplatin, Bevacizumab (TPB) as neoadjuvant chemotherapy and followed by radical hysterectomy. We measured serum SCC levels, tumour volume and blood flow with SMI. We also performed magnetic resonance imaging (MRI) and positron emission tomography (PET). We compared the pathological findings with clinical assessment including physical examination, serum SCC, MRI, PET and vascularisation of SMI. Results: Six patients were enrolled in this study. Three patients were stage 2B, 2 were 3B, and 1 was 4B of cervical carcinoma. The mean age was 62.0, mean maximal diameter of tumour was 5.2 cm, and histological types of all patients were squamous cell carcinoma. At diagnosis, there were 5 patients had high serum SCC and the other one was negative. SMI revealed vascularisation of blood flow clearly in all cases. Though serum SCC was stable in three patients after 1 course of TPB, decreased blood flow was detected by SMI in all cases. All patients could continue 3 courses of TPB. After neoadjuvant chemotherapy, MRI and PET showed complete response (CR) in 4 patients and partial response (PR) in 2 patients. SMI detected blood flow in 5 patients, which could not be detected by colour Doppler. Pathological examination showed 2 cases of pathological CR and 4 cases of pathological PR. SMI could detect the vascularisation of residual tumour in 4 patients. Conclusions:In patients with advanced cervical carcinoma, ultrasound with SMI was useful to monitor the treatment response of chemotherapy and reveal the blood flow of residual tumour. EP29.03Accuracy of 2D ultrasonography in detecting lymph node metastasis in uterine and cervical malignancies at the Philippine General Hospital: a five-year retrospective study Department of Obstetrics and Gynecology, University of the Philippines, Philippine General Hospital, Manila, PhilippinesObjectives: To determine the accuracy of 2D ultrasound in detecting lymph node metastasis in uterine and cervical malignancies. Methods: This is a five-year retrospective, cross-sectional study involving patients with uterine and cervical malignancies (stages IA2 to IIA2) who underwent bilateral pelvic lymph node dissection and para-aortic lymph node sampling. All had 2D ultrasound performed within two months prior to surgery. Ultrasound findings were compared with the gold standard which is the histopathologic result. Results: A total of 319 patients were included, 267 (84%) with uterine cancer and 53 (16%) with cervical cancer.Adenocarcinoma, endometrioid type was the most common histologic type among uter...

Results: In all 24 cases of PHM, the fetuses died in first trimester or within 20mm in CRL. These placental cysts were unrecognised in half cases by ultrasonography in pregnancy. The umbilical cords inserted into the normal placental site in CHMCF cases, and into multiple vesicular area in PMD cases. We recognised the some vessels in these PMD placentas, but few in molar placentas. In all CHMCF cases, the boundary between the normal placenta with fetus and the molar placenta was clear. Moreover, in 3 cases of these, there was fluid around the small cysts. In 2 cases out of 5 PMD, although there were some normal appearance area, the boundary was unclear. In the remaining 3 cases, no normal placental area was found. These all placentas didn't include the fluid area. No fetal anomalies were noted in both CHMCF and PMD. Conclusions: In cases of PHM, fetuses demised in first trimester. The following findings were useful to distinguish PMD from CHMCF in vesicular pattern placenta with a fetus after second trimester; first, the placenta cord was inserted into normal area in CHMCF. Secondary, the placental dividing line was clear, and sometimes vesicular area had fluid and few vessels in CHMCF. The lymphangioma is a non-common cervical lesion that can be diagnosticated by ultrasound in the prenatal period. It can be associated with a large number of pathologies and the evolution is determinate by the association of local damage that it can generate, which can be evaluated prepartum. This clinical case is of a pregnant patient with a cervical lymphangioma that was diagnosticated at the 24 weeks in the obstetric echography of routine. This case was evaluated and managed given the location and size with the EXIT (ex utero intrapartum treatment) procedure at 37 weeks; optimising in this way the management of the airway. In this case, the pathology was diagnosed pre-natal and managed during the partum by an invasive procedure that was fundamental to have a favourable obstetric outcome; we can conclude that the multidisciplinary evaluation is the key to have good results in this type of pathology. EP12: THORAX AND ABDOMENSupporting information can be found in the online version of this abstract We report a case of a 38-year-old pregnant woman who was referred to our centre at 19 gestational week for fetus ventricular septal defect. A reference sonography conducted at the 20th gestational week confirmed the heart condition, and identified a voluminous placental chorioangioma associated to an excess of amniotic liquid. Then, an amniocentesis was realised to verify the fetal karyotype and a DNA microarray, which came back normal with a feminine karyotype. At the 27 gestational week, was found a dilatation of the transverse colon to the rectum, leading us to perform a thorough exam of the fetal pelvis where we noted the two-part uterus with 3D rendered in coronal view. A fetal MRI was performed at the 29th gestational week showing no anomalies at the abdominal and at the pelvis floor. Finally, the patient delivered at 39 gestatio...