Synthesis of Analogues of the O-β-D-RibofuranosylNucleoside Moiety of Liposidomycins. Part 1. Contribution of the Amino Group and the Uracil Moiety upon the Inhibition of MraY. -The study demonstrates that both the amino group and an intact uracil moiety are critical for the inhibition of the bacterial translocase. The primary amine (Ia) can be modified. -(DINI, C.; DROCHON, N.; FETEANU, S.; GUILLOT, J. C.; PEIXOTO, C.; ASZODI, J.; Bioorg. Med. Chem. Lett. 11 (2001) 4, 529-531; Dep. Med. Chem., Aventis Pharma, F-93235 Romainville, Fr.; EN)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.