Abstract-Since the microwave was used for the first time in 1986 in the field of the organic synthesis, the reactions assisted by microwaves are used more and more in the strategies of synthesis. It meets an interest growing because of its great effectiveness and its extreme profitability due to reduced reaction times, better outputs and obtaining purer products. Its particular use, was the subject of a method around whose developed a green chemistry. Several developed, he was devoted, and the last in date is a work C.O. Kappe in 2005. Within the framework of this work, we will try to develop an aspect of the chemistry of the protective groupings: chimioselective protection deprotection of N-Boc-Glucosamine-Acyle by irradiation under domestic microwave. The usual spectroscopic methods ( 1 H NMR, IR and MS) were made profitable for elucidation synthesized structures.