Abstract— The photochemical reaction in aqueous solutions of several phenothiazines with an N‐alkylamine chain, and their salts, is studied by means of Chemically Induced Dynamic Nuclear Polarization (CIDNP)¶. The particular behaviour of chlorpromazine hydrochloride is outlined and evidence is shown for the existence of a substitution product with the solvent at the α‐carbon atom of the side‐chain, and an aldehydic derivative resulting in the cleavage of that one. Radical‐ions pairs of CPZ are involved in both processes.

HI and [''C]photo-CIDNP of a mixture of aqueous chlorpromazine (CPZ) and different pyrimidine and purine bases and nucleotides show polarizations of the starting material excepted when guanine or its nucleotide were used. These polarizations can be explained by means of an electron transfer mechanism from CPZ to the bases. Similar effects are observed with other phenothiazine drugs of the CPZ class. The lonely difference consists in the intensity of the polarized signals of the bases. We try to correlate this intensity with the phototoxic potency of the drug. *Laboratoire de Chimie Organique Physique, associt I'E.N.S.C.L., L.A. C.N.R.S. no 351,

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