The comparative sensitivity and specificity of three immunodiagnostic tests for hydatid disease--the latex agglutination (LA) test, the indirect haemagglutination (IHA) test and the counterimmunoelectrophoresis (CIEP) test--were studied. The results of the IHA test were evaluated using three positivity criteria. Antigen from the same source--hydatid cyst fluid pool of ovine origin--was utilized for the three tests. A total of 123 sera were studied; 30 preoperative sera from patients with other parasitic and infectious diseases, 30 sera from patients with non-parasitic diseases and 30 sera from normal blood donors. The results of the three tests were correlated to the immunoelectrophoresis (IEP) test based on the presence of arc 5. The same sensitivity (86.7%) and specificity (99%) was obtained in LA, CIEP and IHA tests when the minimum cross-reactivity titre criterion was employed for the latter. Non-specificity was relatively high (13%) in the IHA test when only serological reactivity was considered. The sensitivity of the IHA test decreased (83.3%) using the diagnostic titre criterion and non-specific reactions were eliminated. All three tests correlated well with the IEP test.
Familial adenomatous polyposis is very rare in our environment. This condition occurring with a complication of a colorectal cancer has never been reported to the best of our knowledge. We present a case of a 26-year-old Nigerian man who came to us in February this year with a 10-year history of watery stool, which is also mucoid with tenesmus. There was also associated weight loss and colicky abdominal pains. He had also previously had a previous proctoscopy and rectal biopsy that showed numerous adenomatous polyps with dysplastic changes confirmed by histology. Barium enema revealed multiple polyps up to the right side of the transverse colon. Repeat histology after panproctocolectomy confirmed foci of invasive adenocarcinoma of the colon up to the muscle coat. The patient post-operatively is alive and well.
Se describe una nueva variante técnica de la prueba de aglutinación del látex para el diagnóstico de la hidatidosis humana, adaptada al empleo de partículas de látex poliestireno de 0,81 µ de diámetro y antígeno estandarizado mediante análisis inmunoelectroforético.
Se estudiaron 51 sueros de hidatidosis confirmadas quirúrgicamente y 90 sueros control de enfermos no hidatídicos y donantes sanos.
La sensibilidad del método fue de 86,2% y la inespecificidad global de 1,1%. Un caso de teniasis fue positivo.
Se plantean diversas consideraciones respecto a la interpretación de los resultados en serología hidatídica.
Pese a los avances realizados durante estos últimos años, en relación al descubrimiento de factores que intervienen en la producción de hepatitis crónica (HC), su etiopatogenia está aún poco definida. Actualmente. se conocen -factores desencadenantes y predisponentes que con seguridad intervienen en la producción de HC, existiendo otros cuya participación es dudosa (tabla I). Tabla l. FACTORES ETIOPATOGENICOS DE LA HEPATITIS CRONICA A) Factores predisponentes l. Genéticos 2. Sexo
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