Abstract:-Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the class of drugs which are used in the treatment of hypercholesterolemia. They are the most efficient drugs for reducing plasma cholesterol. Mevastatin, also known as compactin is also a statin, catalyzes the conversion of HMG-CoA to mevanolate. Mevanolate is a required building block for cholesterol biosynthesis and mevastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA reductase and thus blocking the enzyme. The present study was carried out on the production of mevastatin by solid state fermentation with Pencillium citrinum MTCC 1256 using sesame oil cake at 28 o C. It deals with the study of parameters such as inoculum age, inoculum volume; nutritional suppliments such as carbon source, nitrogen source and their concentrations were optimized for the effective production of mevastatin.