Selective laser melting (SLM) of Ti6Al4V is a very promising method to produce complex geometries for challenging impact applications. Hot isostatic pressing (HIP) is typically used to improve fatigue behavior, ductility and material reliability of parts produced by SLM. However, this treatment leads to an undesired deterioration of strength. The present study addresses that issue by investigating the effect of two different HIP conditions on the mechanical properties under compression and tensile loading for a strain rate range spanning up to 6 order of magnitudes and two different temperatures. We found a significant tensile-compression anisotropy in both flow stress and strain rate sensitivity depending on the HIP temperatures. These findings was correlated with microstructures and damage mechanisms.