Introduction: This study aimed to determine influenza vaccine coverage and evaluate the knowledge, attitudes and practice about influenza and vaccine of health care workers in Tehran, Iran. .9 % (range, 45% to 62%). Most HCWs (80.6%) had received an influenza vaccination in the past, and 65.4% intended to receive vaccination in the coming year. The main reason given for being immunized was the effectiveness of the influenza vaccine (51.4%). The main reason given for not being immunized was concern about adverse effects (23.1%). The knowledge score for the 35 items ranged from 0 to 34 (mean 17.37). Mean knowledge scores differed between educational levels. There was no significant difference in mean knowledge scores between females and males (P > 0.05). Independent variables (age, sex, marital status, having children aged ≤ 16 years, educational level) were not significant predictors of taking influenza immunization. Conclusion: Despite the high coverage rate of influenza vaccination in our study, we would expect a higher rate because of free vaccine availability. The results indicate the need for on-going education of influenza disease among HCWs to increase vaccination rates.

e451 lower thoracic spinal cord with hyperintense signal in T2 left hemicord. The major capsid protein (VP1) of the Sabin virus T1 isolated in feces showed a 96.5% genetic similarity to Sabin 1 vaccine strain (a 3.5% genetic divergence in this region). Conclusion:The occurrence of iVDPVs appears to be very rare; the majority of patients stopped excretion of the virus after a certain period or have died. The overriding factor for the emergence of all VDPVs is the same as for WPV circulation, i.e., low routine OPV coverage rates in children. Thus, a community can become susceptible to the emergence of all types of VDPV producing an impact in the public health of the population. New polio vaccination strategies should be considered to avoid future VDPV cases and to be aligned WHO endgame strategies.