No abstract

No abstract

No abstract

No abstract

Simultaneous recording of smooth-pursuit eye movements by electrooculographic (EOG) and infrared reflection techniques showed good correspondence between the two methods. The parameter of pursuit arrests, previously used to quantify smooth-pursuit performance, was not well correlated in the two methods. The natural logarithm of the signal:noise ratio obtained from harmonic regression of digitized and standardized eye movement data provides a valid quantitative assessment of smooth pursuit and suggests that such scoring of EOG records is effective and generally free of artifacts.Research performed in this laboratory and elsewhere over the past 4 years has established a possible link between schizophrenia and impairment of smooth-pursuit eye movements (SPEM). Between 65% and 80% of schizophrenic patients and about 45% of their first-degree relatives have shown disordered SPEM. In contrast, the prevalence among normals has been about 6%. Moreover, neuroleptic drugs administered to schizophrenic patients have not accounted for SPEM impairment and single doses of chlorpromazine hydrochloride or diazepam have not disrupted SPEM in normals (Holzman,