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Objective: To understand the associated risk factors in the progression of Diabetic Kidney Disease among the Type 2 Diabetes individuals living in the state of Tamil Nadu and Puducherry. Research design and methods: Clinical and socio-demographic data was collected, digitized, and analyzed for 482 participants diagnosed either with Diabetic Kidney Disease (DKD) or Type 2 Diabetes (T2D). The study was analyzed by using descriptive statistical analysis SAS version 9.4. Results: Out of 482 participants, 422 fulfilled the eligibility criteria. Gender, age, T2D duration, and comorbidity are the major risk factors that are found to be associated with DKD in population understudy. We also found inclination towards usage of insulin among DKD participants rather than oral diabetic medications. Metformin (Biguanides) was the most used oral diabetic medication among the T2D participants followed by DPP-4 inhibitors and Sulphonylureas. Conclusion: Together, these data describe the risk pattern among participants diagnosed with DKD at regional level that is integral in early and proper management of the disease. Keywords: Diabetic Kidney Disease, Diabetic Medications, Insulin, Risk factors, Type 2 Diabetes