HLA and/or HPA alloimmunisation is an important factor to cause refractoriness to platelet transfusions. Crossmatch-compatible platelet transfusion is an effective method in those patients refractory to random platelet transfusions.

A novel human leukocyte antigen-A allele, A*2489, was identified in a Chinese registered donor. The A*2489 allele differs from the closest matching allele A*2428 by two nucleotide substitutions, 257(A-->G) and 265(G-->C), in exon 2.

The B*13:18 allele differs from the most closely matching allele B*13:02:01 by one nucleotide substitution in exon 3, at position 539.

The novel HLA-B*39:46 differs from HLA-B*39:01:01:01 by one base substitution at position 27(C>G) of exon 4.

HLA-A*02:129 differs from HLA-A*02:87 exon 2 at nt 25, nt 29, nt 167 T, nt 184 and nt 192.