Background:The state and motility of a cosmetic ocular prosthesis are important. Purpose: To develop a novel technique of evisceration or enucleation secondary to trauma, chronic uveitis or uveal melanoma, with permanent and removable fixation of the ocular prosthesis in a musculoskeletal stump (MS). Material and Methods: Group 1 comprised 52 patients with chronic uveitis secondary to trauma and phthisis bulbi who underwent evisceration. After evisceration, a polymer composite implant or a polytetrafluoroethylene (PTFE) implant was used to shape an MS with a hole in it for the pegged prosthesis, and the prosthesis motility in these patients was compared with that in the 13 controls in whom an MS without a hole in it for the pegged prosthesis was shaped. Group 2 comprised 31 patients with uveal melanoma who underwent enucleation with a PTFE implant used to shape an MS with a hole in it. The prosthesis motility in these patients was measured and compared with that in the 100 controls in whom an MS without a hole in it for the pegged prosthesis was shaped. Results: In patients of group 1, total prosthesis motility at 3 and 12 months improved to 132.50 ± 6.40 and 147.30 ± 6.70, respectively, versus 103.70 ± 18.30 and 103.10 ± 6.00, respectively, in the controls. No implant exposure was observed over the follow-up period. In three patients of group 2, diastasis of the conjunctival margins with implant exposure was observed at the margin of the hole at months 3 and 7, which necessitated implant removal. In patients of group 2, total prosthesis motility in the four meridians at 3 and 12 months was 141.