In a social-hygienic study, some factors influencing the occurrence and dynamics of the course of gastric ulcer and duodenal ulcer in 379 patients were studied. The results of the data show that the complete staged treatment (polyclinic, hospital, sanatorium) is not carried out for all patients (24.3%) for the entire study period. In the first year of the disease, it was carried out in only 6.8% of patients. To determine the strength of the influence of some socio-hygienic and biological factors on the dynamics of the course of peptic ulcer disease, we used the method of analysis of variance. The analysis of the dynamics of gastric ulcer and duodenal ulcer with the calculation of a static assessment, which reliability is quite convincing, made it possible to conclude with maximum reliability that the dynamics of the disease, in addition to surgical treatment 45.1% (with complications in the form), is most strongly influenced by the nutrition factor 8.5% ... The effect of other factors is approximately the same: material housing conditions 6.6%, the psychological factor 6.5% and working conditions 4.5%.