Sixteen cases of postnatal cytomegalovirus (CMV) infection were identified in a neonatal intensive care unit population over a five year period. Eleven of these infants had gastrointestinal signs at the time of presentation. These ranged from minor and transient (abdominal distension and enteral feed intolerance) to severe and life threatening (protein losing enteropathy, diarrhoea, and hypernatraemic dehydration). An initial diagnosis of necrotising enterocolitis was common, but no infant showed intestinal or hepatic portal pneumatosis. The gestational age of the infants was 24-38 weeks. All had received fresh maternal breast milk. It is suggested that CMV enteritis is added to the spectrum of clinical manifestations of postnatal CMV infection. Signs suggestive of necrotising enterocolitis with atypical features should prompt investigations for CMV infection. P ostnatal cytomegalovirus (CMV) infection has not attracted the attention received by congenital infection as it is held to result in low morbidity. The recognition of severe gastrointestinal symptoms in a small number of preterm infants with postnatal CMV infection prompted a search of the literature and a review of infants admitted to our neonatal unit over a five year period who were known to have postnatally acquired CMV infection.
METHODSInfants were identified as a result of CMV screening in the presence of symptoms such as prolonged jaundice, unexplained enteritis, or signs of systemic sepsis in the absence of positive blood cultures for bacterial sepsis. The standard screen test was the urine CMV DEAFF (detection of early antigen fluorescent foci) test. This is a rapid culture test whereby early CMV antigens are detected by immunofluorescence after the inoculum on a cell sheet is spun for two to four days. The diagnosis of CMV infection was based on the fact that a previously negative urine CMV DEAFF test became positive coincidentally with the onset of clinical symptoms. Urine CMV DEAFF screening of infants at admission was not performed routinely although many of the infants had early screening. However, all of our cases had negative urine CMV DEAFF tests before the positive tests. In cases where the symptomatology was severe, additional tests such as CMV blood IgM and antigen detection were carried out. As the infants were sick preterm babies, it was not feasible to obtain gastrointestinal biopsy samples to confirm the diagnosis of CMV gastrointestinal disease.Our unit feeding policy is to start enteral feeds early once the infant is clinically stable. The preference is for the mother's own breast milk. If not available, then with parental consent, banked breast milk is given. The mother's own milk is given fresh within 48 hours of expression. This milk would have been stored at 4˚C. If fresh mother's milk is unavailable or insufficient, frozen maternal breast milk or banked donor milk is used. Our unit has its own milk bank on site. Milk is obtained from donors who are screened for a panel of viruses (hepatitis B, hepatitis C, HIV-1 and HIV-2,...
An effective accident prevention programme in developing countries requires changes in lifestyle and environment, and overcoming obstacles such as ignorance, illiteracy, and inadequate resources.
Haemangiomas of bone are uncommon lesions, accounting for approximately 1% of all primary bone tumours. The most frequent sites of involvement are the calvaria and the vertebral column. When haemangiomas involve long tubular bones, they are usually found in the diaphysis or metadiaphysis. Juxta-articular or epiphyseal location for a long bone haemangioma is rare. We present the imaging findings in a case of a histopathologically proven juxta-articular intraosseous haemangioma of the proximal femur. We believe ours is the first report of a haemangioma involving the proximal end of the femur.
There are more cases of primary septic arthritis than secondary septic arthritis. Clinicians should be alert of the aetiology shift to gram-negative organisms, in addition to fungal and gram-positive ones. Arthrotomy to drain pus from the joint should not be delayed. Better long-term results can be achieved by early surgical drainage and immediate antibiotic coverage.
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