To reduce a burden of circulatory diseases (CD) is among primary tasks the state has to solve. There are available data on a contribution made by chronic inflammation on occurrence of heart and vascular diseases. Given that, it seems especially interesting to examine impacts exerted by Epstein-Barr virus infection on CD development. The paper focuses on analyzing morbidity with infectious mononucleosis and CD in the Russian Federation over 1995–2018. 103 patients with heart rhythm disorders and 92 blood donors were examined to determine whether they had immunoglobulins to EBV antigens The results were statistically processed involving calculation of Pearson’s linear correlation coefficient, error of cor- relation coefficient, validity coefficient, determination coefficient, and frequencies of EBV markers detection per 100 exam- ined people and their confidence intervals. Differences were considered to be authentic when confidence probability was equal to 95 % and confidence significance was p<0.05. Relative risks of heart rhythm disorders in patients with active EBV- infection were calculated as per results obtained via creating a fourfold table. EBV was established to make a significant contribution into circulatory pathology occurrence and it was confirmed by an overall ascending trend in morbidity with infectious mononucleosis and CD in the Russian Federation in 1995-2018 and an authentic strong direct correlation between these two processes (r=0.94; m=0.02; t=47; p<0.01) with determination be- ing equal to 0.88. Risk of developing heart rhythm disorders was determined by active EBV-infection in case history com- bined with detected M-immunoglobulins to capsid EBV antigen and G-immunoglobulins to early EBV antigen, as well as an increase in concentration of G-immunoglobulins to capsid antigen in blood serum (RR=5.8 and 2.3 accordingly).