Proteins are one of the most important indicators of blood. More than 150 individual whey proteins are currently known. However, an idea of the protein spectrum of blood can also be obtained on the basis of the concentration of total protein, albumin, globulins, the value of the protein coefficient, and the nature of their ratio gives an idea of the direction of protein metabolism (anabolic or catabolic), since the specificity of metabolic processes determines the productivity of layers. The concentration of total protein in the blood of chickens did not depend on the age of the bird, namely the period of the reproductive period, and hence the level of egg production. It fluctuated at the level of 37.2-42.0 g / l. Albumin concentration significantly increased during oviposition from 17.51 ± 1.71 to 21.36 ± 2.09 g / L. At the same time, the percentage of albumin in the total protein concentration increased from 47.07 ± 1.27 (26 weeks of age) to 53.93 ± 1.33% (p≤0.05) (80 weeks of age). The amount of globulins in the blood of hens did not depend on the age and duration of the reproductive period, but had a tendency to decrease, which was the result of a gradual decrease in the defenses of the bird’s body. The resistance of the body of laying hens decreases to the greatest extent at the age of 80 weeks, which causes an increase in Alb / Gl - coefficient by 1.51 times (p≤0.05) compared to the beginning of oviposition. The concentration of urea in the body of hens steadily increased during oviposition from 2.76 ± 0.18 (26 weeks of age) to 4.03 ± 0.11 mmol / L (p≤0.05) (80 weeks of age). The uric acid content in the blood of laying hens did not depend on the age and duration of the reproductive period and varied in the range of 0.39 ± 0.007 - 0.43 ± 0.002 mmol / L.

T HE aim of our research is to study the indicators of growth, development, immunomorphological alteration in the structural components of the spleen during correction of the body of hamsters under experimental loading with biologically active bee-keeping products (BABP), "Microvitum" preparation and their composite forms and without it. There was conducted comprehensive research to identify experience of growth, development, proliferation processes, differentiation, alteration of structural and functional components of the spleen in postnatal ontogenesis of hamsters and under experimental loading on the body with BABP, "Microvitum" preparation and their composite forms. The study found: the dynamics of change in the spleen weight, the absolute values of the average daily liveweight gain of hamsters in postnatal ontogenesis and on the background of introduced BABP (pollen, royal jelly), amino acid-mineral-vitamin preparation "Microvitum" and their composite forms to the diet; macro-and microstructure as well as immunomorphological alteration in the spleen of hamsters in postnatal ontogenesis and under the effect of BABP, "Microvitum" preparation and their composite forms; the relationship of the structural components of the spleen, T-and B-lymphocytes and their populations in the blood that condition immunobiological response of the harmster body in postnatal ontogenesis and ways to correct it with BABP, "Microvitum" preparation and their composite forms; the effect of the experimental loading on immunomorphological response of the spleen, the cellular and humoral component of the immune system and against the background of BABP, "Microvitum" and their composite forms introduced into the diet; ways to correct performance efficiency of hamsters, prevention of cannibalism and female hibernation with BABP, "Microvitum" and their composite forms.

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