Restoration of motor functions in patients with spinal cord injury (SCI) is a priority problem of this patient’s category medical rehabilitation. Despite the achievements of modern medicine, the level of movement restoration after SCI is often insignificant, many patients stayed confined to a wheelchair. Secondary complications (osteoporosis, obesity, cardiovascular, respiratory, urogenital, trophic and other disorders) used to develop in the injured people as a result of low physical activity, they aggravate the course of the main disease and complicate the process of medical rehabilitation. A hope for rehabilitation specialist and patients is associated with the appearance of robotic exoskeletons (RES), that might become an innovation means for improving the mobility of patients with SCI. The purpose of the review is to provide information on the possible benefits and disadvantages of the use of RES in the rehabilitation of patients with SCI. This article discusses the general characteristics of modern exoskeletons and the conditions of their use for patients with paralysis of the lower extremities. The article presents Information on the effectiveness and safety of the use of exoskeleton devices in neurorehabilitation, as well as data on limitations and problems associated with exoskeleton use in clinical practice. The results of meta-analyses and randomized studies on the potential benefits of the RES usage both in everyday life and in rehabilitation of patients with SCI are presented. The influence of walking training in the exoskeleton on the degree of motor functions improvement, overall physical activity level and body weight in patients with SCI is highlighted. The article draws attention to the unsolved problems and further perspectives of RES application in patients with SCI. It emphasizes the necessity for protocols standardization and large randomized comparative clinical trials organization with prolonged observational period of patients in order to determine exoskeletons usage potential.

Relevance. The COVID-19 pandemic is characterized by a long undulating course. One of the directions of the dynamic assessment of the incidence of this infection is, as is known, the characterization of the determinants of the epidemic process and the study of the actual effectiveness of various measures.Aims. Were to study the features of the COVID-19 morbidity in the European, American and Asian regions of the world on the example of individual countries with an assessment of the possible impact of regime-restrictive measures on the daily increase in cases.Materials & methods. A descriptive epidemiological study involved the use of the following data on COVID-19: daily increase in new infections in absolute numbers and relative indicators during 1 June 2020 till 30 November 2020 in five countries (France, Italy, USA, Brazil, India) , description and timing of various restrictive measures. Information obtained from open sources (situation reports from WHO, CDC, ECDC, national ministries of health, etc.). Time series characterized, defining sharply differing values, timing and duration of ups and downs, the rate of average daily growth (decline). Statistical analysis was carried out using the IBM SPSS Statistics 26.Results. On average, for the analyzed period of time, 1303 were registered in Italy, 4897, France – 52799, Brazil – 31853, India –50507new cases. The average incidence rate in the compared countries ranged from 500.98 ± 417.06 per 100,000 in India to 4399.43 ± 2390.77 per 100,000 in the US. After the passage of the «first wave» of the incidence of COVID-19, regardless of the region of the world, there was an increase in the daily increase in new cases of SARS-CoV-2 in the summer-autumn period of 2020. Furthermore, with the differences in the morbidity rates in the different countries, there were also characteristics the formation of similar to the region. For the European region (Italy, France), there was a simultaneous beginning of an increase in the incidence in August-September 2020, a similar trend towards exponential growth and synchronous fluctuations in the daily increase in absolute cases of diseases. For the countries of the American region (USA and Brazil), a similar sinusoidal nature of the dynamics of the average daily increase in infection cases and its synchronicity until October 2020 was revealed. The Asian region, on the example of India, had significant differences in the dynamics of the analyzed indicators in comparison with the countries of the European and American regions. Differences in the formation of morbidity in the summerautumn period were more pronounced between the regions and related to the level of average daily growth, the incidence rate, the month of the maximum rise in the incidence in this period, and trend differences. Comparison of the ongoing isolation measures with the daily increase in cases revealed their discrepancy. This could create the preconditions for the activation of the epidemic process of infection and the ineffectiveness of measures.Conclusions. We found that in the five countries examined, the situation developed according to a similar scenario. Nevertheless, in different regions of the world there was a specificity in the involvement of the territory in the epidemic process. A more in-depth study of the timeliness and completeness of regime-restrictive measures against SOCID-19 should include a comparison with the patterns of formation and manifestations of the epidemic process. In turn, this is important for scientifically based implementation and increasing their effectiveness.