We have studied Corydalis gigantea Trautv. et Mey., family Papaveraceae [i], growing in the Far East.The plants were collected in the Krasnoarmeiskii region in the phase of mass vegetation.An evaporated methanolic extract of 17 kg of the herbage was treated with 5% sulfuric acid, the acid solution was made alkaline with 25% ammonia, and the bases were extracted with chloroform.The combined alkaloids (46.3 g) were separated by the usual method into fractions of phenolic (2.2 g) and nonphenolic (9 g) benzene-soluble bases and a benzene-insoluble fraction (35 g). The fraction of phenolic bases, on chromatography on a column of silica gel with elution by benzene-ethyl acetate (7:3) yielded 0.37 g of l-scoulerine, and elution with ethyl acetate gave 0.55 g of /-cheilanthifoline [2].Crystallization of the benzene-soluble nonphenolic bases yielded 0.64 g of L-adlumine and 1.24 g of protopine.By chromatography on a column of silica gel, the mother solutions yielded 0.13 g of sanguinarine, 0.09 g of dihydrosanguinarine, 1.17 g of d-bicuculline, and 0.14 g of /-adlumidine [3]. The structures of the other bases isolated are being studied. 1 10011. No part o f this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, elec tronic, J mechanical, photocopying, microfilming, recording or otherwise, without written permission o f the publisher. A copy o f this article is available f r o m the publisher f o r $7.50.
We have investigated Corydalis persica Cham et Schlecht, family Papaveraceae, the alkaloid composition of which has not been studied previously. From the tubers collected in the flowering phase (June 1, 1972) in the Bichinakskii Pass we isolated the combined alkaloids (1.63%) by the dichloroethane method. By column chromatography on alumina (activity grade I1) with elution by diethyl ether we obtained a white crystalline optically inactive substance with the composition C~0H15OsN , mp 266-267°C (ether) which was identified as sanguinarine [1]. Elution with diethyl ether-chloroform (97 : 3) gave chelerythrine, C21HlsOsN , mp 208°C (ether) [1]. Elution with diethyl ether-chloroform (95 : 5) gave a substance with the composition C20HlgOsN , mp 204-205°C, which was identical with an authentic sample of protopine [2]. 1o 2.
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