Introduction: Cerebral vein thrombosis (CVT) remains exceptional in inflammatory bowel disease (IBD), and cerebral venous sinus involvement in these diseases is qualified as "uncommon". They typically occur in patients with known and treated IBD but may exceptionally be the first manifestation of the disease. We report an original case of CVT of the right lateral sinus revealing CD.Case report: A 28-year-old woman with no significant pathological history was referred to our department for treatment and etiological assessment of isolated CVT of the right lateral sinus.The somatic examination was without abnormalities. The basic bioassays showed a marked biological inflammatory syndrome. Screening for constitutional and acquired thrombophilias, autoimmune diseases, cancers, and hematological malignancies was negative. Colonoscopy revealed terminal ileitis with multiple aphthous ulcers. Histopathological examination of the ileal biopsies concluded to CD.The patient was treated with systemic corticosteroids, mesalamine, and effective anticoagulation with favorable outcome. Cerebral MRI as well as colonoscopy at six months were without abnormalities, and no thrombotic recurrence has been noted for two years. Conclusion:As rare as it is, this unusual complication of CD deserves to be known by all health practitioners to avoid diagnostic delays and improve the prognosis that is likely to be fatal.

Introduction: hematological disorders are among the so-called unusual manifestations of hypothyroidism, and by far dominated by anemia. Leucocytes abnormalities are less common and often of an autoimmune nature. We report an original case of isolated non-autoimmune neutropenia revealing primary severe hypothyroidism.Case report: A 30-year-old woman was referred by her family doctor for exploration of leucopenia at 3200/mm 3 . Control of the blood count confirmed isolated neutropenia at 600/mm 3 . The other parameters of the total blood count were without abnormalities: hemoglobin at 13g/dl, platelets at 162000/mm 3 , and lymphocytes at 2400/mm 3 . Clinical examination, baseline bioassays, abdominal ultrasonography, thoraco-abdominopelvic CT, and myelogram were without abnormalities. Anti-nuclear, antinative DNA, anti-nucleosome, and anti-neutrophil antibodies were negative.Subsequent investigations concluded to primary hypothyroidism of Hashimoto's thyroiditis: TSH at 182μU/ml, FT4<1 pmol/l, anti-thyroglobulin antibodies at 255 IU/ml, and anti-thyroperoxidase antibodies at 1000 IU/ml. The patient was treated with thyroxine in progressive doses until normalization of TSH with 175μg/d. The evolution was favorable with neutrophils at 2200/mm 3 after one month of treatment. Conclusion:Isolated and non-autoimmune neutropenia indicative of hypothyroidism is exceptional and unusual representing a real diagnostic challenge for clinicians. It is recommended to screen for thyroid dysfunction in front of any leucopenia that does not prove itself.