Introduction Most SLE patients have increased expression of type-I interferon (IFN)-regulated genes, the so-called IFN-signature. 1 IFN-regulated genes are subdivided in 3 modules (M1.2, M3.4 and M5.12). 2 Module 1.2 is associated with disease presence and the latter two seem to be sequentially activated and to correspond with active disease. 3

BackgroundIn our center we observed in preliminar studies that within pregnant SLE patients, Anti-Ro Ab carriers suffered less abortions than non-carriers.ObjectivesIt comes to test whether this results are statistically significant and if there is an association with other variables such as previous abortion and disease activity, described in the literature.MethodsPopulation of 105 SLE pregnant women, atended in our Hospital pregnancy and Lupus Unit. Anti-Ro/La Ab and antiphospholipidic Ab analysis in the 105 patients mentioned. Also analysis of the SLE activity through Lupus Activity Index in pregnancy (LAIP) and Systemic Lupus Erythematosus Disease Activity Index in pregnancy (SLPDAI) tools applied to 88 prospective pregnancies, and the influence of previous abortions.Results32 pregnancies with a history of previous abortion, resulting in 78.13% abortions and 21.87% births.56 pregnancies with no prior history of abortion, resulting in 5.35% abortions and 94.64% births (p<0.0001). 44 pregnancies Anti-Ro carriers, had 22.72% abortions and 77.27% births; and of 61 pregnancies non-carriers, causes 42.62% abortions and 53.38% births; OR:0.396, CI:0166-0944; p<0.05.Other valued Ab presence, has not been significant, neither disease activity.ConclusionsPrevious abortions presence is the most negative influence on pregnancy outcome. Anti-Ro Ab presence is a protective factor of pregnancy. Disease activity does not affect pregnancy outcome, although the observed trend is to increase the abortion risk, enhancing SLPDAI value; we believe this result is determined by selecting pregnancy time in terms of disease activity.ReferencesAnselm Mak, Mike W.-L. Cheung, Alicia Ai-cia Cheak and Roger Chun-man Ho Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression, Rheumatology 2010;49:281–288F. Mecacci, B. Bianchi, A. Pieralli, B. Mangani, A. Moretti, R. Cioni, L. Giorgi, G. Mello and M. Matucci-Cerinic Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies Rheumatology 2009;48:246–249 doi:10.1093H.J.A. Carp, P.L. Meroni and Y. Shoenfeld. Autoantibodies as predictors of pregnancy complications Rheumatology 2008;47:iii6–iii8Evelyn V. Rozenblyum, Sharon Sukhdeo, Edgar Jaeggi, Lisa Hornberger, Philip Wyatt, Carl A. Laskin, and Earl D. Silverman. Anti-Ro and Anti-La Antibodies in the General Pregnant Population: Rates and Fetal Outcomes. ARTHRITIS & RHEUMATOLOGY Vol. 66, No. S11, March 2014, p S63.Monika Østensen, Peter M. Villiger, Frauke Förger. Interaction of pregnancy and autoimmune rheumatic disease, Autoimmunity Reviews 11 (2012) A437–A446.Disclosure of InterestNone declared