~ 97 ~ Издание зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор). Свидетельство о регистрации СМИ ПИ ЭЛ № ФС77-50518 Вестник представлен в научной электронной библиотеке (НЭБ) -головном исполнителе проекта по созданию Российского индекса научного цитирования (РИНЦ)

No abstract

The present research work is vital given the importance of studying risk factors that can cause mortality due to diseases of the circulatory system, especially among population of employable age. Our research aim was to establish what factors might induce developing hypertension based on examining psycho-vegetative status, biochemical and functional parameters of the cardiovascular system in underground workers depending on their age. We examined 109 men who were employed at a chromium mining enterprise and were exposed to occupational and psy-chosocial factors. The patients were divided into two groups; the test group was made up of 60 men who worked under ground under working conditions ranked as “hazardous” and belonging to hazard category 3.3–3.4; the reference group consisted of 49 men who dealt with surface works under working conditions belonging to hazard category 3.2. The test group was further divided into two sub-groups depending on workers’ age: people younger than 45 (n = 20, average age was 38.45 ± 2.95) and people older than (n = 40, average age was 50.90 ± 1.46). The reference group was also divided accordingly. The patients had their psycho-vegetative status examined profoundly with assessing neuropsychic stress, personal and situational anxiety, attention function, and subjective reflection of psycho-vegetative distress. The state of the cardiovascular system (CVS) was examined using results of functional and clinical-laboratory diagnostics. Decreased attention, greater personal anxiety and a greater number of psycho-vegetative complaints were detected authenti-cally more frequently among patients with hypertension (OR 7.50, 95 % CI 2.39–23.58; OR 11.06, 95 % CI 4.35–28.10; OR 22.50; 95 % CI 7.09–71.41). We detected differences in adaptation psycho-vegetative phenotypes between two sub-groups. A correlation between age and working experience and indicators of psycho-vegetative status was established for patients younger than 45 but there was no correlation with homeostasis indicators. There was a negative correlation between age and working experience and some indicators of psycho-vegetative status revealed for patients older than 45; there was a direct correlation between these parameters and certain homeostasis indicators given hypertension diagnosed in 95 % patients in this sub-group. As age and working experience grew, adaptation psycho-vegetative phenotype transformed and the process involved inversion of correlations with psycho-vegetative indicators together with aggravating functional disorders of the CVS. When transformation of this phenotype is diagnosed, it allows assessing risks of developing hypertension and makes for primary hypertension prevention through determining risk groups among workers.

The present research work is vital given the importance of studying risk factors that can cause mortality due to diseases of the circulatory system, especially among population of employable age. Our research aim was to establish what factors might induce developing hypertension based on examining psycho-vegetative status, biochemical and functional parameters of the cardiovascular system in underground workers depending on their age. We examined 109 men who were employed at a chromium mining enterprise and were exposed to occupational and psy-chosocial factors. The patients were divided into two groups; the test group was made up of 60 men who worked under ground under working conditions ranked as “hazardous” and belonging to hazard category 3.3–3.4; the reference group consisted of 49 men who dealt with surface works under working conditions belonging to hazard category 3.2. The test group was further divided into two sub-groups depending on workers’ age: people younger than 45 (n = 20, average age was 38.45 ± 2.95) and people older than (n = 40, average age was 50.90 ± 1.46). The reference group was also divided accordingly. The patients had their psycho-vegetative status examined profoundly with assessing neuropsychic stress, personal and situational anxiety, attention function, and subjective reflection of psycho-vegetative distress. The state of the cardiovascular system (CVS) was examined using results of functional and clinical-laboratory diagnostics. Decreased attention, greater personal anxiety and a greater number of psycho-vegetative complaints were detected authenti-cally more frequently among patients with hypertension (OR 7.50, 95 % CI 2.39–23.58; OR 11.06, 95 % CI 4.35–28.10; OR 22.50; 95 % CI 7.09–71.41). We detected differences in adaptation psycho-vegetative phenotypes between two sub-groups. A correlation between age and working experience and indicators of psycho-vegetative status was established for patients younger than 45 but there was no correlation with homeostasis indicators. There was a negative correlation between age and working experience and some indicators of psycho-vegetative status revealed for patients older than 45; there was a direct correlation between these parameters and certain homeostasis indicators given hypertension diagnosed in 95 % patients in this sub-group. As age and working experience grew, adaptation psycho-vegetative phenotype transformed and the process involved inversion of correlations with psycho-vegetative indicators together with aggravating functional disorders of the CVS. When transformation of this phenotype is diagnosed, it allows assessing risks of developing hypertension and makes for primary hypertension prevention through determining risk groups among workers.

We examined 109 men working at а mining enterprise exposed to occupational and psychosocial factors. The patients were divided into two groups: the main group - 60 men working in underground conditions, the conditions are assigned to classes 3.3 - 3.4; comparison group - 49 men performing ground work, whose conditions are classified as 3.2. In connection with the established diagnosis of "Syndrome of arterial hypertension" in middle-aged people of the main group, it was divided into two subgroups in terms of age - people under 45 years old (n = 20, age 38.45 ± 2.95 years), and people older 45 years old (n = 40, age 50.90 ± 1.46 years.). Purpose: to study the prerequisites for the development of hypertension based on the psychovegetative status and some changes in the biochemical and functional indicators of the CVS, depending on the age-related changes in these indicators. Materials and methods: the patient underwent a study of the psycho-vegetative state with an assessment of the level of neuropsychic stress, personal and situational anxiety, attention function, subjective reflection of psycho-vegetative distress. The state of the cardiovascular system was investigated according to the results of functional and clinical laboratory diagnostics. Results: A decrease in attention, an increase in personal anxiety and an increase in the number of psychovegetative complaints were significantly more often detected in the group of patients with hypertension (OR 7.50; 95% CI 2.39-23.58; OR 11.06 95% - CI - 4.35 - 28.10; CI 22.50; 95% CI - 7.09 - 71.41). Adaptive psychovegetative phenotypes were distinguished in two subgroups. In patients over 45 years old, a negative relationship was established between age, experience and some parameters of psycho-vegetative status, as well as a direct relationship between these parameters and some indicators of homeostasis in the diagnosis of hypertension syndrome in 95% of patients in this subgroup. Conclusions: with an increase in age and experience, there is a transformation of the adaptive psychovegetative phenotype with an inversion of connections with psychovegetative parameters against the background of increased functional disorders of the cardiovascular system. Diagnostics of the transformation of this phenotype makes it possible to assess the risk of developing arterial hypertension and contributes to the prevention of hypertension by forming risk groups.