Background: The immune system plays an important role in various diseased conditions. Patients with compromised immune function are at increased risk of exposure. Thus, the evaluation of immunomodulatory activity of plant extracts may be helpful for prophylactic treatment approach. Objectives: The aim of present study is to evaluate the effect of methanolic extract of Neolamarckia cadamba Linn. fruits for antioxidant, immunomodulatory and anticancer properties using in-vitro and in-vitro models. Methods: In the present investigation, antioxidant property of methanolic extract of Neolamarckia cadamba fruits (NCM) was evaluated by superoxide radical and DPPH scavenging activity. The immunomodulatory property of NCM extract was analysed by determining cytokines release (IL-2 and TNFα) in murine primary thymocytes. The effects of NCM extract on humoral and cellular immunity was analysed under in vivo conditions. The anticancer activity of the extract was evaluated on Jurkat J6 cell line by MTT assay. Results: The methanolic extract of Neolamarckia cadamba fruits showed superoxide and DPPH free radical scavenging antioxidant activity and significantly increased the cytokines release (IL-2 and TNFα) in murine primary thymocytes. The increased hemagglutination antibody titre and neutrophil adhesion as well as the restoration of cyclophosphamideinduced myelosuppression and DTH response confirm the stimulatory effect of NCM on T cells. In-vitro results on Jurkat J6 cell line showed the significant increase in cell death confirming its anticancer activity. Conclusion: Thus, it can be concluded that the methanolic extract of the fruits of Neolamarckia cadamba possesses antioxidant activity, immunomodulatory property as well as anticancer potential, suggesting its therapeutic efficiency in the treatment of immune disorders as well as cancer.

ABSTRACT-The present study was carried on Abelmoschus esculentus (A. esculentus) by using the vermicompost.The decoction tea powder is wasted wet garbage and discarded on the dumping ground. It generally creates environmental pollution. This wet garbage can used as a good source of nutrients to the vegetable crop plants. The research is carried out by preparing vermicompost using 75% decoction tea powder and 25% mixture of black soil, cow dung, leaf litter and little vermicompost. The compost prepared by using decoction tea powder has increased concentration of necessary nutrients such as pH, minerals, organic carbon (O.C.), total phosphorus, potassium, calcium, magnesium and sodium required for vegetable crop plants for its development. In present investigation by applying this compost, Electrical conductivity was decreased by 9.51%, O.C. 89.30%, total phosphorus 26.09%, potassium 1.0%, Mg and Na by 43.17% shows a significant increase in absorption. It is also observed that germination period decreases whereas height of stem, leaf area, flowering and fruits were developed earlier than control soil.