No abstract

Two case reports involving drugs suspected of causing toxic epidermal necrolysis, that have not been previously implicated in this rare cutaneous drug reaction, are presented.

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by the formation of benign nerve sheath tumours known as neurofibromas. A 28-year-old female presented with a large neurofibroma extending from the elbow of the right arm into the axilla and across the right breast. A mastectomy was performed to excise 4 kg of tissue with an immediate flap reconstruction. Post-operatively, the patient’s hemoglobin levels dropped significantly due to excessive blood loss, but the patient was discharged by post-operative day 5 with no additional complications. This study raises awareness for NF1, describes possible complications that may arise following excision of highly vascularized neurofibromas, and outlines possible techniques for breast reconstruction.

A review of the Hamilton experience over a 10-year period, discussing treatment trends, etiology and outcomes is presented.

Two case reports involving drugs suspected of causing toxic epidermal necrolysis, that have not been previously implicated in this rare cutaneous drug reaction, are presented.