No abstract

prediction, and differs by 2.9-4.10* from three recent measurements.:I: 0.0025(stat.) zb 0.0015(sys.) ps"1, which is consistent with the QED rate values consistent with each other. The combined result is Ag : 7.0398 are carried out with two different types of SiO; powder, resulting in decay errors in all the previous experiments. Two independent measurements of the extrapolation, which might have been sources of the main systematic rate can be determined without the ambiguities of the thermalization nor errors. From Eq.(1), the population of o -Ps, N(t), is expected to obey the following entirely new method, which is free from above-mentioned systematicWe report here on a new measurement of the 0 -Ps decay rate with the extrapolation to zero density might be a source of another systematic error.the multiple scattering at the surface of the materials [15]. Therefore the linear materials are conjectured to be more complicated due to the processes such as the one between single rigid balls. However the collisions of the 0 -Ps with the materials is only valid, if the coliision between the 0 -Ps and the material is like the assumption of the linear dependence of Apickojf on the densities of the target unthermalized o-~Ps could result to a large systematic error [13, 14]. Furthermore there seems to exist no concrete evidence to support this assumption, and the yielded the A0, assuming that the velocity of the o -Ps was constant. However, varying densities of the target materials, and the extrapolation to zero densities of the material. In all the previous experiments, the /1.,,;,, 's were measured by pickoff annihilation rate is a function of time, which depends on the properties ultimate thermal energy of about 0.03 eV ('thermalization'), the corresponding eV immediately after formation, and slows down by elastic collisions toward the and to the velocity of the 0 -Ps. Since the 0 -Ps has a. kinetic energy of about 1 materials, and is consequently proportional to the densities of the target materials The /\,,;,,;,.,,·_,· is proportional to the rate at which the 0 -Ps collides with the /\¤¤»·(*) Z Ac + )*p<¤k¤:r(*)( 1) annihilation rate, /\,,,,,;,,,,·,·, i.e.decay rate, /\,,;,,, is the sum of the the intrinsic decay rate, A0, and the pickoff colliding with the atomic electrons of the target material, the observed 0 --PsBecause some portion of 0 -Ps inevitably causes the 'pickoff' annihilation by without any evidence so far [7, 8, 9, 10, 11, 12].to clarify the discrepancy, various exotic decay modes have been searched for, discrepancy, being 6.7, 6.3 and 4.30, is statistically very significant. In an effort ppm) than the theoretical QED calculation corrected up to O(cz2) [4, 5, 6]. This performed, which reported decay rate values much larger (by 1400, 1300 and 920Three precision measurements [1, 2, 3] of the o --Ps decay rate were recently the constituent leptons interact only through the electromagnetic interactions.direct information about quantum electrodynamics(QED), since to higher order decays slowly into three ph...

BackgroundTo identify potential therapeutic target in clear cell renal cell carcinoma (ccRCC), we performed a transcriptome analysis. Our analysis showed that fatty acid binding protein 7 (FABP7) has the highest mean differential overexpression in ccRCC compared to normal kidney. We aimed to investigate the significance of FABP7 in ccRCC.MethodsImmunohistochemical staining for 40 advanced ccRCC cases was performed to investigate correlation between clinicopathological parameters and FABP7. They were composed of 40–83 years old cases with 33 male, 22 cases with pT ≥ 3, 19 cases with M1, and 16 cases with grade 3. The effect of gene knockdown was analysed by a cell viability assay and invasion assay in FABP7-overexpressing cell lines (SKRC7 and SKRC10).ResultsOur immunohistochemical analysis showed that higher FABP7 expression significantly correlated with distant metastasis and poor cancer-specific survival (CSS; both p < 0.05). Functional suppression of FABP7 significantly inhibited SKRC10 cell growth (p < 0.05) and resulted in a significant reduction of the invasive potential (p < 0.01), but did not cause growth inhibition of SKRC7 cells. We found that The Cancer Genome Atlas Research Network (TCGA) database shows FABP6 and 7 as equally overexpressed in the FABP family. Functional suppression of fatty acid binding protein 6 (FABP6) resulted in significant growth inhibition of SKRC7 cells (p < 0.005).ConclusionsFunctional suppression of FABP7 significantly reduced cell viability and invasive potential in a ccRCC cell line. FABP7 may play a role in progression in some metastatic ccRCCs. The suppressed function may be compensated by another FABP family member.

The quenching processes of the thermalized ortho-positronium(o-Ps) on an oxygen molecule have been studied by the positron annihilation age-momentum correlation techinique(AMOC). The Doppler broadening spectrum of the 511 keV γ-rays from the 2γ annihilation of o-Ps in O2 has been measured as a function of the o-Ps age. The rate of the quenching, consisting of the pickoff and the spin-conversion, is estimated from the positron lifetime spectrum. The ratio of the pickoff quenching rate to the spin-conversion rate is deduced from the Doppler broadening of the 511 keV γ-rays from the annihilation of the o-Ps. The pickoff parameter 1 Z eff , the effective number of the electrons per molecule which contribute to the pickoff quenching, for O2 is determined to be 0.6 ± 0.4. The cross-section for the elastic spin-conversion quenching is determined to be (1.16 ± 0.01) × 10 −19 cm 2 .