The immune system provides resistance of the organism against bacterial and viral infections in the body of the poultry. In the intestinal mucosa of eymeria it was secrete metabolic products, that are toxic to various systems and tissues of turkeys. Eymeria, parasitizing in the gut, inhibit specific phase of immunity presented by antibodies (humoral type), reduce the activity of sensitized cells (cell type), slow down nonspecific phase of immunity, represented by various immune cells. The rapid and complete recovery of functional state of the immune system in turkeys, affected by eymeriozic invasion it was found if brovitatoxide was given if the aggregate of the fruits of milk thistle. Fruits contain group of flavius lignans named «Sylimaryn», acting immune stimulatory for the development of secondary immuno deficiencies state of body.

Antibiotic resistance of the main infectious disease pathogens is one of the biggest problems of present time, which causes the need for searching for new antimicrobial medicinal substances and developing effective medicinal agents. One of the innovative medicinal preparations with the antimicrobial action, which is recommended for application for animals with hoof diseases, is FORTICEPT TM Hoof Oinment. Integration in the practice new medicinal preparations needs their strict toxicological control, which involves the exploring of acute and chronic toxicity and remote effects of possible side effect. The purpose of work was the determination of the acute toxicity parameters of the FORTICEPT TM Hoof Oinmentduring the oral administration to white laboratory mice and evaluation of the skin resorptive action of the preparation after it was administrated on rats' skin. For determination of the acute toxicity there were used male laboratory mice with the average weight of the body 20 g -two groups with 10 animals in each. For the first group (the control one) with the help of the probe there was injected the distilled water (0.1 ml) into stomach. For the second group there was injected FORTICEPT TM Hoof Oinment (0.1 g), where the dose of the preparation is equal 500 mg/kg. For evaluation of the skin resorptive action of the preparation there were used 6 white rats with the average weight of the body 175 g. On the pre-prepared patch of skin there was administrated the preparation in the number that is equal 2857 mg/kg of body weight. For control there was leaved a free from preparation patch of bare skin. Exposition lasted for 4 hours. The indicators were explored in dynamics after 6, 24, 48 hours from the exposition started. After the research results there was established that FORTICEPT TM Hoof Oinment doesn't cause death after its intragastric administration to the white laboratory mice in the number that is equal 5000 mg/kg of the body weight, that's why depending on the degree of toxicity it belongs to the V toxicity class (Practically nontoxic). After one-time application of the preparation to the white rats in the number which is equal 2857 mg/kg of the body weight there wasn't observes no death or pronounced changes in the behavior reactions, motor activity, state of the nervous system, amount of the consumed food and water. Therefore FORTICEPT TM Hoof Oinmentaccording to the results of the determination of the acute toxicity after its administration on the skin to the white rats depending on the degree of toxicity it belongs to the V toxicity class (Practically nontoxic). FORTICEPT TM Hoof Oinment doesn't detect skin resorptive action, that points on the absence of toxic effects of the preparation due to its application on the skin.

Unfortunately, in the 21st century, humanity is pondering the devastating consequences that weapons of mass destruction can inflict on us. The reason for this is the inevitable severe damage to animals and people in this case and the first steps of medical care that must be provided to the victims. Weapons of mass destruction are nuclear, chemical, and biological, each of which has uniquely harmful effects on macro-organisms and the environment. The result of a nuclear explosion is radioactive pollution of the environment and the occurrence of radiation sickness in animals under the influence of radionuclides. The nuclear wave causes injuries and burns in animals of varying degrees of complexity and localization. Xenobiotics, as a quick-acting chemical weapon, cause skin-burning (moisture, nitrogen mustard, lewisite), nerve-paralytic (zoman, sarin, V-gases (Vx-gases), suffocating (phosgene, diphosgene, triphosgene, thiophosgene, chlorine), general poisoning (hydrocyanic acid and chlorocyanine) and irritating (chloroacetophenone, Ci-Es (CS), Ci-Ap (СR), adamsite) effects on macroorganisms with specific clinical manifestations. The characteristic of substances with a skin-irritating effect is the ability to affect the skin by forming blisters and ulcers, which are difficult to treat. Disorders of the functions of the nervous system, muscle spasms, and paralysis are characteristic clinical signs of exposure to nerve-paralytic substances. Suffocating xenobiotics causes pulmonary edema and respiratory arrest, and overall tissue respiratory depression. Irritation of the eyes with subsequent development of conjunctivitis and upper respiratory tract with the rapid development of edema is characteristic of substances with an irritating effect. In most cases, each chemical compound received its name after the developer’s name. Most of them were first used in the First World War. Most of the xenobiotics mentioned above are prohibited by the Chemical Weapons Convention of 1993.

In the article the brought results over of sharp and chronic toxicness of new preparation dextran of iron «Ferosel Т», that in the composition contains Iron and Selenium. It was set that preparation of «Ferosel Т» in prophylactic and therapeutic doses and in a dose in 3 times of any more than therapeutic, at peroral introduction a 3 twenty-four hours in succession did not show a toxic action laboratory rats. At the terms of hypodermic introduction of preparation the death of white rats it was not, it is only set brief oppression of laboratory animals, animals preparations were given that in a dose 10 ml/kg. It is set that in prophylactic and optimal therapeutic doses preparation did not influence on the detoxication function of liver. For rats, what was entered Ferosel T in maximal therapeutic and maybe toxic doses, duration of a dream from Hexenalum was on 32 and 35 percents more relation than control sizes. The toxicness of Ferosel Т was also studied on the indexes of irritating action(after dermic test and testis on conjunctiva), action of allergy (a method of applique on a skin) and determined the coefficients of mass of internalss at great while of introduction of preparation. For animals Ferosel Т was entered that in a dose 10 ml/kg during a 21 twenty-four hours, motive activity some went down. Research of emotional and behavior reactions of laboratory animals after introduction of Ferosel Т during a 21 twenty-four hours in therapeutic and maximally therapeutic doses did not show substantial influence on the nervous system. On the indexes of hyperemia and edema of skin and thickness of skin fold of Ferosel Т in prophylactic and therapeutic doses at an applique on the skin of crawls did not cause a local irritating action. Separate injection of preparation of «Ferosel Т» for 0,1 ml did not cause the filling out reaction of paws guinea-pigs. As a result of undertaken studies it is not educed allergen properties at preparation of «Ferosel Т». For laboratory rats, Ferosel Т was entered that in a prophylactic dose it is not set reliable changes of coefficients of mass of heart, liver, spleen and kidneys. For rats Ferosel Т was entered that in an optimal therapeutic dose, in comparing to control mass of spleen and liver was accordingly on 10.3 and 6.4% anymore. At introduction of Ferosel Т to the maximally therapeutic dose mass of spleen and liver was accordingly on 14.0 and 15.0% anymore. The got results of researches specify that preparation of Ferosel Т is safe at application for a prophylaxis and treatment of animals.

Antibacterial agents are one of the most important groups of medical preparations  in the treatment of bacterial infection of different localization in humane and in veterinary medicine. The consequence of their rational use (the establishment of sensitivity of the pathogenic microflora, compliance with the course of treatment, etc.) have a high therapeutic effect and the minimum development of resistant strains of microorganisms. The widely used  group of antimicrobial agents in veterinary medicine are second-generation fluorohinolone antibiotics that have good pharmacokinetic properties, a broad spectrum of bactericidal activity, and relatively low toxicity, although they have their own warnings and restrictions on the use of small animals during the formation of bone tissue. To achieve high therapeutic efficacy and minimizing of side effects, it is described the compatibility of some fluoroquinolones with other pharmacological groups. They found their application in the treatment of both productive animals, poultry, fur animals and petty domestic (dogs and cats) with a bacterial infection of the urinary tract, digestive and respiratory systems, infected wounds, etc. The article describes the detailed mechanism of action of the antibiotics of the fluoroquinolone group, which provides an opportunity for a deeper understanding of the manifestation of the bactericidal effect, as well as their classification by generation or generation. Particular attention deserves attention to the time of carrenia of fluoroquinolones in the context of their application to productive animals, because high quality livestock products minimize the development of resistant strains in humans and provide them with health. There is also a list of all registered medicinal products registered in Ukraine containing: ofloxacin, enrofloxacin, ciprofloxacin, marbofloxacin, denofloxacin, which carries important informative information for practicing doctors, pharmacists, etc.