Aim: The present study explored the pharmacological and insilico studies of ethanolic seed extract of Chenopodium quinoa. Materials and Methods: The screening of in vivo anti- amnesic activity of the ethanolic seed extract of Chenopodium quinoa was carried out using Actophotometer and Rotarod apparatus. The extract exhibited active constituents like myristic acid, palmitic acid, eicosadienoic acid, pentadecanoic acid, tocopherols, stigmasterol, β-sitosterol, quercetin, benzoic acid, kaempferol, arachidonic acid, benzofuran and 2-bromodecanoic acid. In silico approaches like docking studies (Mcule software) and Ramchandran plot (procheck), online softwares were used in the study to establish mechanism of action of active constituents present in the extract. Results: The extract treated groups at doses (200 mg/kg and 400 mg/kg, bd.wt) showed significant anti-amnesic activity. The basal activity score in actophotometer is as an indicator for impairment of learning and memory. Fall of time by rotarod is used to evaluate learning and memory in rodent models of CNS disorders as in case of amnesia. The results revealed that quercetin, kaempferol, myristic acid, palmitic acid, stigmasterol, lenolenic acid, pentadecanoic acid, tocopherols, arachidonic acid and standard donepezil have got highest glide scores against selected Protein Data Bank (PDB ID): 1EVE, 2FY4, 7CUM and 3EJ8. According to Ramachandran plot a good quality model would be expected to have over 90% in the most favoured region. Proteins like PDB ID: 1EVE, 2FY4, 7CUM and 3EJ8 showed almost 80-90% favoured region which clearly indicates that the selected proteins in the present study are of good quality. Conclusion: Our research unveiled that ethanolic seed extract of Chenopodium quinoa possessed significant anti- amnesic activity.

Objective: The present study was undertaken to evaluate nephroprotective activity of ethyl acetate and methanolic extract of the fruits of against paracetamol and gentamicin induced toxicity using male Wistar rats. Illicium verum Material and Methods: Randomly selected animals were divided into five groups of six animals each. The test extracts were administered orally at a dose of 200 mg/kg and 400 mg/kg. Nephrotoxicity was induced in rats by Paracetamol and gentamicin. The effect of extracts of at doses 200-400 mg/kg.b.wt compared with standard; was Illicium verum determined using serum urea, creatinine and uric acid. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. Results: Paracetamol and gentamicin produced significant biochemical (increase in blood urea, serum creatinine, and serum uric acid level) changes, histological (damage to nephrons) changes, induced by paracetamol and gentamicin in kidney parameters. Pretreatment with extract significantly (p<0.005) prevented the physical, biochemical, and histological Illicium verum changes induced by paracetamol and gentamicin in the kidney The ethyl acetate and methanolic extract. Conclusion: of the fruit at two different dose level (200 & 400 mg/kg, bd.wt) was found to possess significant Illicium verum nephroprotective activity against paracetamol and gentamicin induced toxicity.