No abstract

No abstract

The trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor widely expressed in the mammalian brain, particularly in limbic system and monoaminergic areas. It has proven to be an important modulator of dopaminergic, serotoninergic, and glutamatergic neurotransmission and is considered to be a potential useful target for the pharmacotherapy of neuropsychiatric disorders, including schizophrenia. One of the promising schizophrenia endophenotypes is a deficit in neurocognitive abilities manifested as mismatch negativity (MMN) deficit. This study examines the effect of TAAR1 partial agonist RO5263397 on the MMN-like response in freely moving C57BL/6 mice. Event-related potentials (ERPs) were recorded from awake mice in the oddball paradigm before and after RO5263397 administration. The RO5263397 (but not saline) administration increased the N40 amplitude in response to deviant stimuli. That provided the MMN-like difference at the 36–44 ms interval after the injection. The pitch deviance-elicited changes before the injection and in the control paradigm were established for the P68 component. After TAAR1 agonist administration the P68 amplitude in response both to standard and deviant stimuli was increased. These results suggest that the MMN-like response in mice may be modulated through TAAR1-dependent processes (possibly acting through the direct or indirect glutamate NMDA receptor modulation), indicating the TAAR1 agonists potential antipsychotic and pro-cognitive activity.

No abstract

This study compares the effectiveness of the frequency-based recognition of short acoustic stimuli in groups of adolescents with attention deficit and normal measures of attention in conditions of the standard "oddball" paradigm. Stimuli of duration 50 msec yielded insignificant intergroup differences, though adolescents with attention deficit discriminated signal of duration 11 msec significantly worse. These showed significant differences in evoked brain potentials even with standard stimuli, with a significantly greater amplitude for N2b waves and a decreased P3b component. Evoked potentials obtained in response to the deviant stimulus were characterized by a P3b wave of reduced amplitude in the group with attention deficit. These data provide evidence that adolescents with attention deficit show defined abnormalities in the processing of acoustic sensory information at the cortical level.