The efficacy of sulpiride depends on serum concentrations of serotonin. It can be assumed that serotonin concentration is a marker of sulpiride treatment efficacy in patients with anxiety disorders.

BACKGROUND: In recent years, the demand for feminizing and masculinizing hormone therapy has increased significantly among transgender people around the world. There are no such studies in Russia and the amount of medical information on the transgender population is limited.AIM: to assess the number of transgender patients who take hormone therapy without a doctor’s prescription and to characterize the medicines they use.MATERIALS AND METHODS: data from 1117 transgender patients were included in to analysis: 44.01% (n=515) of them were trans women, 55.99% (n=630) were trans men. Patients applied to the “Scientific Center for Personalized Medicine” in order to receive medical care.RESULTS: Half of transgender people (53.6%) are already taking hormonal drugs. More often transgender women (76.7%), less often transgender men (32.3%). In this case, only 8.6% turned to endocrinologists for the therapy prescription. Many patients used unlicensed drugs, use irrational schemes and combinations, often overdose.CONCLUSION: A significant number of transgender people start using hormone replacement therapy on their own initiative, without the doctor’s supervision. The solution to this problem could be incensement of knowledge level in doctors and patients to create a friendly environment and productive interaction between therapists, endocrinologists and transgender people, as well as the organization of consulting centers within public medical institutions.

Objective: to identify potentially reversible clinical and socio-demographic factors influencing the social adaptation of patients with gender incongruence (GI). Materials and methods: a retrospective analysis of 926 patient records with MtF and FtM GI was performed. Results: among the patients who applied, 44.38% were MtF, 55.62% were FtM. The mean age was 24.0 years (from 13 to 65 years). The educational level of patients is mainly represented by higher (44.2%) and specialized (22.3%) education, 43% of persons lived in the village, 57% - in urban areas. The majority of those who applied grew up in a complete family (82.02%). The first manifestations of GI started mainly in the prepubertal (26.4%) and parapubertal (61.6%) period (up to 13 years). The average age of accepting oneself as a transgender person was 17.0 years. Steps to reduce dysphoria and receive specialized care are usually taken after the age of 20. 83.1% of transgender patients had depressive episodes, and a third (38.5%) had autoaggression. Additional psychiatric diagnoses were present in 24.5% of patients and are represented by 3 groups of diseases: group 1 (6.2%) — potentially reversible neurotic disorders; group 2 (14.1%) — background mental illnesses that are not the cause of GI; group 3 (4.3%) — other mental states with “ideas of sex change”. Conclusions: improvement of social adaptation and prevention of emotional and psychological experiences in persons with GI, assistance is possible at several levels: family, educational institutions, medical community, patient organizations.

Цель исследования. Настоящее исследование направлено на поиск объективных критериев электроэнцефалографии (ЭЭГ) шизофрении с использованием дискриминантного анализа, получение линейной дискриминантной функции (ЛДФ) с чувствительностью и специфичностью не менее 85%. Материал и методы. Обследовали 83 пациента с шизофренией и 116 человек без психической патологии, сопоставимых по основным характеристикам. ЭЭГ регистрировали в формате edf с использованием 16 отведений по системе «10-20» и ушных референтных электродов с последующим спектральным и когерентным анализом. Результаты. В результате проведенного дискриминантного анализа были получены ЛДФ, из которых отобрана формула, включающая 5 предикторов. Среди предикторов наибольшую диагностическую значимость имели показатели мощности бета2 и тета-ритмов в отведении F3. Значимыми предикторами также оказались межполушарная когерентность тета-ритма в отведениях Т5-Т6 и внутриполушарная когерентность бета-ритма в отведениях F3-C3 и T3-C3. Все предикторы входят в данную формулу со знаком минус, т.е. увеличивают вероятность отнесения ЭЭГ к классу шизофрении. Заключение. Методика отбора параметров ЭЭГ, перебора вариантов их сочетаний для получения ЛДФ и верификации результатов дает исследователю мощное и гибкое средство для проведения дискриминантного анализа ЭЭГ, позволяющее в короткие сроки, без рутинных процедур получить линейные дискриминантные функции, проводить предварительную диагностику при помощи экспертной системы, основанной на полученной ЛДФ, оценивать эффективность лечения по динамике итогового дискриминантного балла ЛДФ. Следует ожидать, что по мере лечения шизофрении и изменения модулей предикторов значения функции могут увеличиваться или уменьшаться в зависимости от знака предикторов в ЛДФ, что может служить индикатором успешности применения данной терапии.

In foreign literature on research into the etiopathogenesis of autism spectrum disorders (ASDs), the division of this group of diseases into two forms is getting more and more frequent. These two forms are 'syndromal' and 'non-syndromal' forms of autistic disorders. The literature review aims to cover the issues of the dichotomous classification of ASDs based on the genetic and molecular psychiatric views on the etiopathogenesis of this group of diseases. It also covers the purpose of this classification, the opportunities of its usage in routine clinical practice and the network resources, which allow classifying a form of ASD correctly. Special attention is paid to the multidisciplinary approach to dichotomous classification and its difference from the clinical view on the systematization of autism and the importance of this method for selection of target therapy.