The objective of the study is to develop a practically applied methodology and a mathematical model that considers the requirements for transportation of dangerous goods, the technical condition of rolling stock, modes of work and rest of drivers on the routes of intercity transportation, customers’ requirements, and the interests of the trucking company. The functioning of motor pool while transporting dangerous goods is presented as the relationship between transportation of goods and performance of technical maintenance. A proposed approach to planning takes into account the correspondence of the effective number of technical maintenances to the standard required value for a certain period for vehicle fleet carrying out transportation of oil products; compliance of rolling stock output with the volume of oil products that might be delivered and unloaded in the current month; compliance of time of movement of drivers to a specialised resting place on the intercity route with time established for the modes of work and rest. The mathematical model makes it possible to determine output of the motor pool in each month, considering that transportation of oil products, started last month, ends only in the current one. The mathematical model of operating the vehicle fleet during transportation of oil products includes assumptions related to fulfilment of the requirements for motor pool and the driver, which are specified in the Agreement concerning the International Carriage of Dangerous Goods by Road, Decision of the Customs Union Commission dated 09.12.2011 No. 877 (revised on 21.06.2019). Special attention was paid to planning of vehicle operations when volumes of oil products transported are growing during the construction and renewal of roads. The algorithm of the methodology was used to plan operation of motor pool when transporting BND 90/130 bitumen from the city of Omsk in intercity traffic and was the basis for making management decisions on the implementation of the suggested indicators in a motor transport enterprise practice.

The hepatoprotective properties of the silymarin and the plant alkaloid berberine combinationin experimental paracetamol-inducedliver damage were studied. Silymarin was obtained from milk thistle seeds. The conditions for extraction of flavonolignans (silymarin) were optimized. 70 % ethyl alcohol, ethyl acetate and water were used as extractants. It was shown that the optimal conditions for the extraction of flavonolignans in order to obtain the maximum yield of flavonolignans were alcohol extraction in a Soxhlet apparatus. The experiment showed that the combined of silymarin and berberine was greater than their individual actions, which most effectively permitted stabilization of hepatocyte membranes and prevented altering their integrity in paracetamol-induced toxic liver damage. The self-emulsifying system with silymarin and berberine to a greater extent a significant extent prevented dystrophic changes in hepatocytes and necrosis in liver tissue, reduced hyperfermentemia in rat blood serum, prevented disturbance in the activity of thioredoxin reductase and enzymes of the glutathione antioxidant system and there by more effectively prevented hepatocyte functional impairment.