Nanotechnology has emerged as promising field in insect pest management. Aedes aegypti (Linnaeus) a well-known vector of dengue, chikungunya, and dengue haemorrhagic fever has no commercial management practice for their eradication at the larval stage. In the present study, copper sulphide one of the most detoxified form of copper with biopotential properties was synthesised by standard methodology using sonochemical irradiation method and was evaluated for their larvicidal potential against Ae. aegypti. Treated larvae were observed for various morphological changes as compared to control. Larvae were most susceptible to CuSNPs at 7 ppm showing 100% mortality within 24 h. LC50 and LC90 values calculated with the help of POLO software were 4.42 and 5.73 ppm. The epithelium layer of treated larvae was damaged as compared to control. Remarkable results of copper sulphide nanoformulations at low dosage against Ae. aegypti larvae advocates their further exploration for vector control programmes.