We report an extremely rare case of bilateral Non-Hodgkin lymphoma of maxillary sinus. Although most types of lymphoma have good response to chemotherapy especially in the early stages, our patient demonstrated resistance to the chemotherapy. Spinal metastases resulted in dismal end. The usual R-CHOP regimen was not effective prevent spread even after 4 cycles. Intrathecal CNS prophylaxis as methotrexate is advisable to prevent extension of the disease to the brain and spinal cord.International Journal of Human and Health Sciences Vol. 03 No. 02 April’19. Page: 116-119