Calendula arvensis (CA) had been reported in traditional Moroccan medicine to exhibit its extensive use to treat pain and inlammation. Therefore, the objective of this study was to evaluate the anti-inlammatory activity of CA lowers. The methanol, aqueous, and hexane extracts (ME, AE, and HE) were investigated for inlammatory efects by using two methods, namely, carrageenan and experimental trauma-induced hind paw edema in rats and using indomethacin (20 mg/kg body weight) as a standard drug. The results demonstrated that Calendula Arvensis CA extracts had signiicant anti-inlammatory activity where the HE at the doses of 300 and 500 mg/kg p.o. (p < 0.001) had the best signiicant reduction and inhibition of edema with 51.08, 71.33 and 63.38, 67.33% induced by carrageenan and on experimental trauma induced rat paw edema at third hour, respectively, and similar as compared with standard drug indomethacin 20 mg/kg body weight p.o.(p < 0.001). These results indicate that it could be suggested as contributory efects to the use of CA lowers in the management of inlammation and pain conditions.