No abstract

A regioselective synthesis is reported of a series of polysubstituted 1,2,4-triazoles and 4,4′- and 5,5′-bi-(1,2,4-triazoles) via 1,3-dipolar cycloaddition reactions of nitrilimines with some aza- and diaza-butadiene derivatives.

Quinoline and isoquinoline react with 2-(bromoacetyl)benzothiazole (1) in dry benzene to give the corresponding quinolinium and isoquinolinium salts 2 and 10 which undergo base-mediated [3+2] 1,3-dipolar cycloaddition with some acetylene and ethylene derivatives to give the corresponding benzothiazole-containing pyrrolo[1,2-a]quinoline and pyrrolo[2,1-a]isoquinoline derivatives.

Triazole derivatives R 0280Regioselective Synthesis of Novel 4,4'-and 5,5'-Bi-(1,2,4-triazole) Derivatives. -1,3-Dipolar cycloaddition reactions are reported between aza-and diazabutadienes (II), (V), and (VIII) and nitrilimines generated in situ from (I) and (VII). -(FARAG*, A. M.; DAWOOD, K. M.; KHEDR, N. A.; J. Chem. Res. 2007, 8, 472-474; Dep. Chem., Fac. Sci., Cairo Univ., Giza 12613, Egypt; Eng.) -M. Bohle 07-118