Background: The objective of the study was to determine the perceptions and attitudes toward social media professionalism among pharmacy students according to gender and program year. Methods: An online survey was sent to pharmacy students. The survey contained two sections: a demographics section, and assessment of attitudes toward professionalism and accountability in using social media. Results: About 30% of female students disagreed on using social media for hiring decisions compared to 20% of male students. About 41% of female students agreed on the importance of editing social media profiles prior to applying for jobs, compared to 38% of male students. Male students (11%) agreed more than female students (4%) on taking pictures of others without their knowledge. Fifth-year students (85%) disagreed the most on posting descriptions of how to break school or job rules. Conclusion: Gender and program years have impacted the perceptions and attitudes toward social media professionalism.