Anorectal melanoma (ARM) is a rare, aggressive disease. Given that it presents with local symptoms that resemble other common benign anorectal conditions, ARM is often low on the differential diagnosis. Delayed diagnosis and nonconsensus of treatment options lead to poor prognosis. Here, we report the case of an 85-year-old woman with a history of Irritable bowel syndrome who presented with altered bowel habits and bleeding per rectum. CT revealed a rectal mass with metastatic lesions to the bone, liver, and lungs. Immunohistochemical staining was positive for Human Melanoma Black-45, melanoma antigen recognized by T cells, and SRY-related HMG-box 10. A final diagnosis of ARM was made.

Abu-Rumaileh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Diagnosis of synchronous multiple primary lung cancers (SMPLCs) is a challenge as multiple lesions on chest CT imaging can be misdiagnosed as more common entities such as metastatic disease or infections. The possibility of multiple primary lung cancers should always be considered. Accurate diagnosis can significantly change the management and prognosis. We report a case of a 57-year-old woman, an exsmoker with chronic obstructive pulmonary disease (COPD), who was found to have synchronous endobronchial carcinoid tumor and adenocarcinoma of the lung. The association of carcinoid tumors and adenocarcinoma of the lung has been infrequently reported, with only a handful of cases published to date. Early diagnosis of resectable tumors can improve survival in patients with SMPLCs.