Background: When used prior to a bowel injury, oral antibiotic bowel preparation (OABP) reduces intraluminal bacteria l load and, thus, the risk of surgical site infection (SSI). Objective: The aim of the current study was to investigate the role of preoperative oral antibiotic in gynecological oncology surgery in field visualization, reducing postoperative ileus and surgical site infection. Patients and methods: A cohort study was conducted on a total of 130 women who underwent tumor debulking surgery for gynecological cancer (ovarian, uterine, cervical or endometrial). On the day before surgery, patients received perioperative prophylactic oral antibiotics, and on the day of surgery, all patients were subjected to intravenous cephalosporin. Results: Preoperative oral antibiotic was associated with SSI incidence of 15.4%; 20 cases with surgical site infection (SSI) and 110 cases without SSI. Also favorable surgical field (reported as good or sufficient) was reported in 92.4% of cases. Return of intestinal function was early with mean duration of 19 hours. Conclusion: Preoperative oral antibiotic was associated with low incidence of SSI. Favorable operating field and early return of Bowel function.