Background: Neonatal sepsis (EOS) is among one of the leading cause of death that usually occurs due to infection in the first month of life and can be the result of various maternal and neonatal contributing factors. Objectives: To determine maternal and neonatal contributing factors for early onset of sepsis in neonates. Study design: cross sectional study Period: From 13th April 2019 to 12th Oct 2019. Settings: Neonatal units of pediatric medicine of central park teaching hospital Lahore and Bhatti international hospital Kasur. Material and methods: After approval from hospital ethical committee total 151 neonates were selected using non-probable consecutive sampling. Neonates of both gender who were having gestational age >30 weeks with early onset sepsis were enrolled. Patients who had received antibiotics before presentation were excluded. 5ml of venous blood after proper sterilization was taken from all patients and sent to hospital laboratory for WBC count, CRP and blood culture. Data was entered in pre-designed Performa and analyzed using SPSS 20. Results: There were total 151 patients in study, minimum and maximum age was 1 day and 7 days respectively with mean age of 3.66±1.88 days. Mean gestational age was 35.5±2.6 weeks and mean birth weight was 2.2±1.4 kg. There was slight increase in female patients 51% and 49% males. Among maternal contributing factors maternal fever was found in 64.9%, premature rupture of membrane was found in 43%, foul smelling liquor in 37.1% and meconium-stained amniotic fluid was found in 33.1% neonates. Among neonatal contributing factors prematurity was found in 66.2% low birth weight was present in 64.2%, and low APGAR score was present in 56.6 % neonates. Data was stratified for gender and contributing risk factors but p value was not statistically significant. Data was stratified for gestational age and p value was significant for prematurity, low birth weight and offensive smelling liquor. Conclusion: Prematurity, low birth weight, low APGAR score and maternal fever were significant contributing factors in EOS. Keywords: EOS, Neonatal contributing factors, Maternal contributing factors

The most common complication 0f the third stage of labour is postpartumhaemorrhage, which remains a leading cause of maternal mortality (25.0%), especially indeveloping countries. In developed countries, 3-5% of deliveries are complicated by postpartumhaemorrhage: in developing countries, it is 50 times more common .Third stage of labourwhich exceeds 30 minutes is associated with a significant risk of postpartum haemorrhage andpuerperal infection. The best preventive strategy for these complications is active managementof third stage of labour. Active management includes administration of oxytocin within oneminute of birth of baby. Objectives: To compare the mean blood loss after administration ofintra umbilical oxytocin versus intravenous oxytocin at anterior shoulder for active managementof third stage of labour. Study Design: Randomized controlled trial. Period: Six months from1-1-2013 to 30-06-2013. Setting: Department of Obstetrics and Gynaecology, Unit-III JinnahHospital Lahore. Methodology: 100 patients fulfilling selection criteria were included in thestudy from labour room. These patients were randomly divided into two groups by usinglottery method. Group-A, 50 patients were administered 10 units of oxytocin diluted in 20ml ofnormal saline intraumbilically and group-B, 50 patients were administered 5 units of oxytocinintravenous stat at anterior shoulder. Total blood loss was noted after complete delivery ofplacenta. Results: Mean age was 25.0±3.9 and 24.4±3.5 in group-A and B, respectively. Meangestational age was 38.20±0.96 weeks in group-A and 38.40±0.94 weeks in group-B. Meanblood loss in intraumbilical oxytocin group was 311.20±27.23 ml and in intravenous oxytocingroup mean blood loss was 373.60±66.47 ml. There was statistically significant differencebetween two groups (p<0.001). In group-A 15 patients (30.0%) and in group-B 20 patients(40.0%) were primigravida while remaining patients were multigravida. Conclusion: The usageof intraumbilical oxytocin in active management of third stage of labour is beneficial in reducingthe blood loss in third stage and thus helps in preventing postpartum haemorrhage.