Phytophthora palmivora is a destructive plant pathogenic oomycete that has caused lethal diseases in a wide range of hosts. It is a pan-tropical distributed pathogen that can infect plants at all growth stages. Extensive studies have linked P. palmivora to severe diseases in several crops, such as black pepper, rubber, cocoa, and durian, causing global economic losses. This review covers the following topics in depth: (i) P. palmivora as phytopathogen; (ii) identification and infection mechanism in rubber, cocoa, and durian; and (iii) management and control applied for P. palmivora diseases. Effective management strategies were studied and practiced to prevent the spread of P. palmivora disease. Genetic resistance and biocontrol are the best methods to control the disease. A better understanding of P. palmivora infection mechanisms in our main crops and early disease detection can reduce the risk of catastrophic pandemics.