Aim of work Assessment of left and right ventricular functions in overweight and obese females using different echo-Doppler modalities. Methods This study included 32 obese females (group I), 26 overweight females (group II) -both of them have no chronic illnesses- in addition to 25 healthy females (group III) as a control group. All of them had hsCRP level measured. The following parameters were measured using 2D echocardiography: LA, Ao, LA/Ao ratio, LV measures included LV dimensions, 2D LVEF, 2D LV global longitudinal strain (LVGLS), average LV Sm, Em, Am, LV E/Em ratio, LV E, A and LV E/A ratio. RV measures included LV dimensions, RV FAC, RV Tei index, TAPSE, RV Sm, Em, Am, Em/Am ratio, RV E, A, E/A ratio and PASP. Results hsCRP, LA, Ao, LV dimensions, Average LV Am, E/Em, RVD1, RV Tei and PASP were significantly higher in group I compared to group III, but group I had significantly lower LV E/A, LV Sm, Em, LVGLS, RV E/A, Em/Am and RVGLS compared to group III. Group II had significantly higher hsCRP, Ao and RV Tei and significantly lower LV E/A ratio and LV Em compared to group III. On the other hand, group, I had significantly lower average Sm, LVGLS and RVGLS than group II but no significant difference detected between two groups as regard LV and RV diastolic function. Pulse, BMI, BSA, waist circumference, waist to hip ratio, hsCRP were negatively correlated with LVGLS and RVGLS. Cut-off values for BMI showed good sensitivity and specificity to predict impaired LVGLS and RVGLS. Cut-off point 31.9 kg/m2 for impaired LVGLS with sensitivity 80%, specificity 76.81% and p value <0.001, cut-off point >30.73kg/m2 for impaired RVGLS with sensitivity 80%, specificity 69.57% and p value 0.001. Waist circumference was the most sensitive predictor for impaired LVGLS and hsCRP for impaired RVGLS. Conclusion Isolated obesity and overweight are independent predisposing factors for impaired LV and RV systolic and diastolic dysfunctions. TDI and 2D STE are good echo-Doppler modalities to detect subclinical effects on LV and RV functions. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.

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Introduction Right heart function is an important predictor of morbidity and mortality in patients with cardiovascular diseases having left ventricular (LV) systolic dysfunction. Aim Assessment of right ventricular (RV) and right atrial (RA) functions in heart failure patients using strain imaging and three-dimensional echocardiography. Patients and methods This study included 60 patients (group I) having LV systolic dysfunction with LV ejection fraction less than or equal to 40% in addition to 20 healthy participants (group II) as a control group. LV measures included 2D and 3D-LV ejection fraction, LV-Tei index, and 2D and 3D-LV global longitudinal strain. RV measures included RV dimensions, RV fractional area change, RV-Tei index, 2D-RV global longitudinal strain, 3D-RV ejection fraction, 3D-average longitudinal strain for both interventricular septum, and RV free wall (3D-RVLS-sept and 3D-RVLS-FW, respectively). RA measures included RA dimensions, RA passive, active and total emptying volumes and fractions, peak RA longitudinal, and contractile strain. Parameters of LV, RV, and RA functions were compared between groups I and II. Results RV and RA dimensions and volumes, and LV-Tei and RV-Tei indexes were significantly higher in group I compared with group II. All other parameters of LV, RV, and RA function except RA-active emptying volumes were significantly lower in group I compared with group II. Cutoff values for parameters of RV and RA function showed good sensitivity and specificity to discriminate group I from group II. Cutoff points were 19.9% for 2D-RV global longitudinal strain, 46.4% for 3D-RV ejection fraction, 11.7% for 3D-RVLS-sept, 18.6% for 3D-RVLS-FW, 29.2% for peak RA longitudinal, and 17.1% for peak RA contractile strain. Sensitivity ranged from 78.3 to 96.7% and specificity ranged from 85 to 100% with a P value of less than 0.001. Conclusion RV and RA functions are impaired in heart failure patients with LV systolic dysfunction. Both 3D and strain imaging are good echo modalities in the evaluation of right heart function.